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FLASH GENE

Symbol

XRCC2

contributors: mct/npt/pgu - updated : 15-06-2009

HGNC name	X-ray repair complementing defective repair in Chinese hamster cells 2
HGNC id	12829

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Nervous brain         Reproductive female system breast mammary gland   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to RAD51

Homologene

FAMILY	RECA family
	RAD51 subfamily

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	XRCC2 and other HR proteins, including the key recombinase RAD51, co-localize with the centrosome

basic FUNCTION	promoting the repair of DNA double strand breaks by homologous recombination by faciliting
	RAD51-dependent recombination repair
	with BRCA2 protein are required for homologous recombination (but XRCC2 is not involved in transcription-associated recombination, TAR)
	RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
	RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair

CELLULAR PROCESS

nucleotide, repair, recombination

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

pathway in cells for the repair of severe DNA damage such as double-strand breaks

a component

INTERACTION

DNA

RNA

small molecule

protein

RAD51D

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   cells deficient in XRCC2 show disruption of the centrosome, a key component of the mitotic apparatus

Susceptibility

to breast cancer with younger-onset to ovarian carcinoma

Variant & Polymorphism	R188H polymorphism increase the risk of breast cancer
	XRCC2 rs3218536, R188H, showed some evidence of a protective association for the rare allele
	XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk
	XRCC2 SNPs may influence breast cancer risk and survival

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS