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FLASH GENE
Symbol XRCC2 contributors: mct/npt/pgu - updated : 11-12-2013
HGNC name X-ray repair complementing defective repair in Chinese hamster cells 2
HGNC id 12829
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to RAD51
Homologene
FAMILY
  • RECA family
  • RAD51 subfamily
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • XRCC2 and other HR proteins, including the key recombinase RAD51, co-localize with the centrosome
  • basic FUNCTION
  • promoting the repair of DNA double strand breaks by homologous recombination by faciliting
  • RAD51-dependent recombination repair
  • with BRCA2 protein are required for homologous recombination (but XRCC2 is not involved in transcription-associated recombination, TAR)
  • important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
  • CELLULAR PROCESS nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway in cells for the repair of severe DNA damage such as double-strand breaks
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAD51D
  • HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FANCR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    cells deficient in XRCC2 show disruption of the centrosome, a key component of the mitotic apparatus
    Susceptibility
  • to breast cancer with younger-onset
  • to ovarian carcinoma
  • Variant & Polymorphism
  • R188H polymorphism increase the risk of breast cancer
  • XRCC2 rs3218536, R188H, showed some evidence of a protective association for the rare allele
  • XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk
  • XRCC2 SNPs may influence breast cancer risk and survival
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS