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FLASH GENE
Symbol WNT8B contributors: - updated : 11-04-2006
HGNC name wingless-type MMTV integration site family, member 8B
HGNC id 12789
Location 10q24      Physical location : 102.222.811 - 102.243.397
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - D10S571 - ENTPD1 - D10S1680 - D10S208 ,DNTT - D10S574 - D10S577 - D10S198 ,GOT1 - D10S603 - WNT8B - D10S1268 - D10S1265 - D10S192 ,PAX2 - qter
Authors Gray (97)
Physical map
COX15 10q24 COX15 homolog, cytochrome c oxidase assembly protein (yeast) CGI-32 10q24.31 CGI-32 protein ABCC2 10q24 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 KIAA1010 10q25.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 CPN1 10q24.31 carboxypeptidase N, polypeptide 1, 50kD KEO4 CHUK 10q24-q25 conserved helix-loop-helix ubiquitous kinase FLJ10998 10q24.31 hypothetical protein FLJ10998 MGC10120 10q24.31 hypothetical protein MGC10120 PKD2L1 10q24-q25 polycystic kidney disease 2-like 1 SCD 10q23-q24 stearoyl-CoA desaturase (delta-9-desaturase) LOC90271 10q24.31 hypothetical protein LOC90271 WNT8B 10q24 wingless-type MMTV integration site family, member 8B SEC31L2 10q24.32 SEC31-like 2 (S. cerevisiae) NDUFB8 10q23.2-q23.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HIF1AN 10q24 hypoxia-inducible factor 1, alpha subunit inhibitor PAX2 10q22.1-q24.3 paired box gene 2 C10orf6 10q24.31 chromosome 10 open reading frame 6 SEMA4G 10q24.2 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G MRPL43 10q24.1-q24.3 mitochondrial ribosomal protein L43 PEO1 KIAA1813 10q24 KIAA1813 protein FLJ23209 10q24.32 hypothetical protein FLJ23209 BA108L7.2 10q24.32 similar to rat tricarboxylate carrier-like protein FKSG28 10q24.32 hypothetical protein FKSG28
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Reproductivefemale systemovary   
Respiratoryrespiratory tractlarynx   
 respiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text in developing forebrain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
cysteine rich with a zinc finger-like motif
conjugated GlycoP
HOMOLOGY
interspecies homolog to Drosophila wingless (Wg) segment polarity gene
Homologene
FAMILY
  • member of the WNT family encoding intercellular signaling molecules
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • may be playing key roles in embryonal tumors and embryonic stem cells through synergistic activation of CTNNB-TCF signaling pathway
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for partial epilepsy
    Marker
    Therapy target
    ANIMAL & CELL MODELS