Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GOT1 contributors: mct/npt - updated : 08-10-2019
HGNC name glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
HGNC id 4432
Location 10q24.2      Physical location : 101.156.627 - 101.190.530
Synonym name
  • aspartate aminotransferase 1
  • growth-inhibiting protein 18
  • transaminase A
    • Synonym symbol(s) AATC, GIG18, AST1, ASTQTL1, cAspAT, cCAT
    EC.number 2.6.1.1/2.6.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 33.90 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see WNT8B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2140 - 413 - 2017 28716744
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinethyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text efficiently packaged into COPII vesicles and cycled rapidly between the ER and Golgi compartments (Lorente-Rodríguez 2009)
    basic FUNCTION
  • playing a role in amino acid metabolism and the urea and tricarboxylic acid cycles
  • may have an unexpected role in vesicle formation from the ER by influencing membrane properties (Lorente-Rodríguez 2009)
  • is essential for redox balance and growth in pancreatic ductal adenocarcinoma
  • GOT1 may play a role in the maintenance of cellular redox homeostasis
  • plays an important role in energy metabolism and ROS balance in chronic acidosis stress
  • regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements
  • is crucial to provide oxaloacetate at low glucose levels, likely to maintain the redox homeostasis
  • GOT1, GOT2 catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and alpha-ketoglutarate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal-phosphate
    • protein
  • HIF1A acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic GOT1 and mitochondrial GOT2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ETV6/GOT1 fusion in a case of t(10;12)(q24;p13)-positive myelodysplastic syndrome (Struski 2008)
    Susceptibility to Macro-aspartate aminotransferase (macro-AST)
    Variant & Polymorphism
  • missense variant (p.Gln208Glu, rs374966349) in GOT1 was found, as a putative causal variant predisposing to familial macro-AST
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    therapy target in pancreatic ductal adenocarcinoma (PDAC)
    cancerendocrinepancreas
    small molecule inhibitors that target GOT1 could serve as starting points for the development of new therapies for pancreatic cancer
    cancer  
    is a possible target in cancer therapy
    ANIMAL & CELL MODELS