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FLASH GENE
Symbol DNTT contributors: - updated : 12-07-2006
HGNC name deoxynucleotidyltransferase, terminal
HGNC id 2983
Location 10q24      Physical location : 98.064.084 - 98.098.319
Synonym name
  • DNA nucleotidylexotransferase
  • nucleosidetriphosphate:DNA deoxynucleotidylexotransferase
    • Synonym symbol(s) TDT
    EC.number 2.7.7.31
    DNA
    TYPE functioning gene
    STRUCTURE 34.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map see WNT8B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2071 - 509 - Thai
    - - 2068 - 508 - Thai
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     thymus   highly
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines malignant preB and preT lymphocytes
    fluid/secretion
    at STAGE
    Text in a restricted population of normal pre-B and pre-T lymphocytes during early differentiation,
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		BRCT adaptor domain,(BRCA1 C-terminus)
    HOMOLOGY
    Homologene
    FAMILY DNA polymerase type-X family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION encoding a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    magnesium
    protein interacting with PRPF19 and DNTTIP1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS