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FLASH GENE
Symbol WFDC2 contributors: mct - updated : 20-06-2011
HGNC name WAP four-disulfide core domain 2
HGNC id 15939
Location 20q13.12      Physical location : 44.098.393 - 44.110.171
Genatlas name epididymis-specific gene product
Synonym name
  • human epididymis protein 4
  • Synonym symbol(s) HE4, WAP5, RP3-461P17.2, EDDM4, MGC57529
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 11.78 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TOMM34 20q12-q13.11 translocase of outer mitochondrial membrane 34 STK4 20q11.2-q13.2 serine/threonine kinase 4 KCNS1 20q12 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 WFDC5 20q13.11 WAP four-disulfide core domain 5 WFDC12 20q12-q13.1 WAP four-disulfide core domain 12 PI3 20q12-q13 protease inhibitor 3, skin-derived (SKALP) SEMG1 20q13.1 semenogelin I SEMG2 20q13.1 semenogelin II LOC149709 20q13.12 similar to RIKEN cDNA 1700049M11 SLPI 20q12-q13.2 secretory leukocyte protease inhibitor (antileukoproteinase) MATN4 20q13.1-q13.2 matrilin 4 RBPSUHL 20q12-q13.1 recombining binding protein suppressor of hairless (Drosophila)-like SDC4 20q13.1 syndecan 4 (amphiglycan, ryudocan) C20orf35 20q13.12 chromosome 20 open reading frame 35 C20orf10 20q12-13.12 chromosome 20 open reading frame 10 PIGT 20q12-q13.1 phosphatidyl inositol glycan class T LOC149710 20q13.12 hypothetical LOC149710 WFDC2 20q12-q13.2 WAP four-disulfide core domain 2 WFDC6 20q13.12 WAP four-disulfide core domain 6 SPINLW1 20q12-q13.2 serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) WFDC8 20q13.12 WAP four-disulfide core domain 8 WFDC9 20q12-q13.1 WAP four-disulfide core domain 9 WFDC10A 20q13.12 WAP four-disulfide core domain 10A RPS2L1 20q13.11 ribosomal protein S2-like 1 WFDC11 20q12-q13.1 WAP four-disulfide core domain 11 WFDC10B 20 WAP four-disulfide core domain 10B WFDC13 20q13.12 WAP four-disulfide core domain 13 LOC391253 20 similar to dJ601O1.1 (novel protein with Kunitz/Bovine pancreatic trypsin inhibitor domain) HNRPA1P3 20q13.12 heterogeneous nuclear ribonucleoprotein A1 pseudogene 3 WFDC3 20q13.12 WAP four-disulfide core domain 3 DNTTIP1 20q13.12 deoxynucleotidyltransferase, terminal, interacting protein 1 UBE2C 20q12-q13.1 ubiquitin-conjugating enzyme E2C TNNC2 20q12-q13.11 troponin C2, fast C20orf161 20q13.11 chromosome 20 open reading frame 161
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 570 - 124 - 1998 9685187
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
     epididymis     Homo sapiens
    Digestivemouthtongue  highly Homo sapiens
     salivary gland   highly Homo sapiens
    Respiratorylung     Homo sapiens
     respiratory tracttrachea  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide followed by an acidic and cysteine rich polypeptide
  • two WAP domains, WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
  • a conserved motif, containing eight cysteines
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to proteinase inhibitous,four disulfide core proteins
    Homologene
    FAMILY
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • potentially involved in sperm maturation
  • a putative serum tumour marker for ovarian cancer
  • may be a component of the innate immune defences of the lung, nasal and oral cavities
  • functions in concert with related WAP domain containing proteins in epithelial host defence
  • its expression is associated with cancer cell adhesion, migration and tumor growth, which can be related to its effects on the EGFR-MAPK signaling pathway
  • participates in the process of ovarian cancer cell maturation and is responsible for engaging the progression of the ovarian cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays an important role in ovarian cancer cell migration and spreading
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian carcinomas
    tumoral     --over  
    significantly increased in patients with transitional cell carcinoma (TCC)in the urinary system compared to patients with benign urinary diseases patients
    constitutional     --over  
    Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence
  • measuring WFDC2 in urine may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
  • may be a screening tool for early diagnosis of TCC in the urinary system, and may become a prognostic marker for TCC in the urinary system
  • novel and specific biomarker for epithelial ovarian cancer (EOC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
    ANIMAL & CELL MODELS