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FLASH GENE
Symbol WFDC2 contributors: mct - updated : 20-06-2011
HGNC name WAP four-disulfide core domain 2
HGNC id 15939
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in ovarian carcinomas
tumoral     --over  
significantly increased in patients with transitional cell carcinoma (TCC)in the urinary system compared to patients with benign urinary diseases patients
constitutional     --over  
Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis (
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • its expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence
  • measuring WFDC2 in urine may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
  • may be a screening tool for early diagnosis of TCC in the urinary system, and may become a prognostic marker for TCC in the urinary system
  • novel and specific biomarker for epithelial ovarian cancer (EOC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
    ANIMAL & CELL MODELS