Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WFDC2 contributors: mct - updated : 20-06-2011
HGNC name WAP four-disulfide core domain 2
HGNC id 15939
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide followed by an acidic and cysteine rich polypeptide
  • two WAP domains, WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
  • a conserved motif, containing eight cysteines
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to proteinase inhibitous,four disulfide core proteins
    Homologene
    FAMILY
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • potentially involved in sperm maturation
  • a putative serum tumour marker for ovarian cancer
  • may be a component of the innate immune defences of the lung, nasal and oral cavities
  • functions in concert with related WAP domain containing proteins in epithelial host defence
  • its expression is associated with cancer cell adhesion, migration and tumor growth, which can be related to its effects on the EGFR-MAPK signaling pathway
  • participates in the process of ovarian cancer cell maturation and is responsible for engaging the progression of the ovarian cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays an important role in ovarian cancer cell migration and spreading
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian carcinomas
    tumoral     --over  
    significantly increased in patients with transitional cell carcinoma (TCC)in the urinary system compared to patients with benign urinary diseases patients
    constitutional     --over  
    Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence
  • measuring WFDC2 in urine may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
  • may be a screening tool for early diagnosis of TCC in the urinary system, and may become a prognostic marker for TCC in the urinary system
  • novel and specific biomarker for epithelial ovarian cancer (EOC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
    ANIMAL & CELL MODELS