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FLASH GENE
Symbol TSSK6 contributors: mct - updated : 14-09-2020
HGNC name testis-specific serine kinase 6
HGNC id 30410
Location 19p13.11      Physical location : 19.625.028 - 19.626.469
Synonym name
  • FKSG82
  • serine/threonine protein kinase SSTK
  • testis secretory sperm-binding protein Li 205a
  • cancer/testis antigen 72
    • Synonym symbol(s) FLJ24002, SSTK, TSSK4, CT72, FKSG82
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 1.33 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1330 - 273 - 2010 20829357
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivemale systemtestis   
    Urinarybladder    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
  • TSSK1, TSSK2 and TSSK6 were detected in human sperm
    • at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a protein kinase domain
    HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, SNF1 subfamily
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized to the heads of elongating spermatids
    basic FUNCTION
  • required for proper postmeiotic chromatin remodeling and male fertility, for sperm production and function
  • plays a role in DNA condensation during
    • postmeiotic chromatin remodeling
  • is a proacrosin-binding protein
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    magnesium
    protein
  • interacts and has functional relationship to the regulatory protein SNF4
  • interacts also with SIP1
  • interacts with the heatshock proteins HSPCB, HSPA8 and HAPA1A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS