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FLASH GENE
Symbol TSSK6 contributors: mct - updated : 14-09-2020
HGNC name testis-specific serine kinase 6
HGNC id 30410
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Reproductivemale systemtestis   
Urinarybladder    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
  • TSSK1, TSSK2 and TSSK6 were detected in human sperm
  • at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a protein kinase domain
    HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, SNF1 subfamily
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized to the heads of elongating spermatids
    basic FUNCTION
  • required for proper postmeiotic chromatin remodeling and male fertility, for sperm production and function
  • plays a role in DNA condensation during
  • postmeiotic chromatin remodeling
  • is a proacrosin-binding protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    magnesium
    protein
  • interacts and has functional relationship to the regulatory protein SNF4
  • interacts also with SIP1
  • interacts with the heatshock proteins HSPCB, HSPA8 and HAPA1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS