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FLASH GENE

Symbol

TSSK6

contributors: mct - updated : 14-09-2020

HGNC name	testis-specific serine kinase 6
HGNC id	30410

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032037 1 - 1330 NP_114426 - 273 - 2010 20829357

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Reproductive male system testis       Urinary bladder

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid

cell lineage
cell lines
fluid/secretion	TSSK1, TSSK2 and TSSK6 were detected in human sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a protein kinase domain

HOMOLOGY

Homologene

FAMILY

ser/thr protein kinase family, SNF1 subfamily

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	localized to the heads of elongating spermatids

basic FUNCTION	required for proper postmeiotic chromatin remodeling and male fertility, for sperm production and function
	plays a role in DNA condensation during
	postmeiotic chromatin remodeling
	is a proacrosin-binding protein

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	magnesium

protein	interacts and has functional relationship to the regulatory protein SNF4
	interacts also with SIP1
	interacts with the heatshock proteins HSPCB, HSPA8 and HAPA1A

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS