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FLASH GENE
Symbol TRPV3 contributors: mct - updated : 21-03-2018
HGNC name transient receptor potential cation channel, subfamily V, member 3
HGNC id 18084
Location 17p13.3      Physical location : 3.416.485 - 3.461.289
Synonym name
  • vanniloid receptor-like 3
  • vanilloid receptor-related osmotically activated channel protein
  • Synonym symbol(s) VRL3
    DNA
    TYPE functioning gene
    STRUCTURE 44.80 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3420 - 790 - 2007 17521436
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainponstrigeminal ganglia  Homo sapiens
     gangliasensory gangliadorsal root   Homo sapiens
     spinal cord     Homo sapiens
    Skin/Tegumentskin   highly Homo sapiens
     skin appendageshairfollicle   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text skin
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four ankyrin domains at the N terminus, and a critical CaM-binding site with an essential aspartic acid at the pore loop that contribute to the sensitization of TRPV3
  • six transmembrane spanning domains, with a pore forming region bretween transmembrane domains 5 and 6
  • a C terminal cytoplasmic tail
  • HOMOLOGY
    interspecies homolog to murine Trpv3
    intraspecies homolog to TRPV1,TRPV4
    Homologene
    FAMILY TRPV family (vanillo
    d channel family)
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the formation of heteromeric vanilloid receptor channels, that underlie the thermal hypersensivity of sensory neurons at site of tissue injury
  • TRPV3, rather than TRPV4, mainly participates in transmission of warm temperature information from keratinocytes to adjacent nerve endings through ATP release
  • present in absorptive cells in the distal colon and may be involved in a variety of cellular functions
  • involved in behavioral responses to innocuous and noxious heat
  • required for the formation of the skin barrier by regulating the activities of transglutaminases, a family of Ca(2+)-dependent crosslinking enzymes essential for keratinocyte cornification
  • heat-activated transient receptor potential ion channel expressed in keratinocytes, inducing nitric oxide production via a nitrite-dependent pathway
  • TRPV3 and nitrite are involved in wound healing and thermosensory behaviours
  • plays essential roles in skin keratinization, hair growth, and possibly itching sensation
  • role of TRPV3 as a strong modulator of cutaneous vascular thermoregulatory mechanisms (
  • roles for TMEM79 and TRPV3 in thermosensation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRPV1 (contributing to TRPV1 response)
  • TRPV3 regulatory region is a target for MBTPS2
  • TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of CALCA peptide and nitric oxide in response to local heating of the skin (
  • TMEM79 modulated TRPV3 translocalization and promoted its degradation in the lysosomes
  • cell & other
    REGULATION
    activated by Farnesyl Pyrophosphate
    inhibited by Ca2+ from both the extracellular and intracellular sides
    Other thermosensitive ion channel, but capsaicin insensitive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in injured brachial plexus nerves
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • good candidate for future therapy in skin inflammation and pruritus
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    targeting TRPV3 could provide therapeutic potential for keratinization or itching-related skin disorders.
    ANIMAL & CELL MODELS
  • mutation of TRPV3 is linked to defective hair growth and dermatitis in rodents
  • mice lacking the Trpv3 gene also exhibit wavy hair coat and curly whiskers