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FLASH GENE

Symbol

TRPV3

contributors: mct - updated : 21-03-2018

HGNC name	transient receptor potential cation channel, subfamily V, member 3
HGNC id	18084

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain pons trigeminal ganglia   Homo sapiens   ganglia sensory ganglia dorsal root     Homo sapiens   spinal cord         Homo sapiens Skin/Tegument skin       highly Homo sapiens   skin appendages hair follicle     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Nervous central       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

skin

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four ankyrin domains at the N terminus, and a critical CaM-binding site with an essential aspartic acid at the pore loop that contribute to the sensitization of TRPV3
	six transmembrane spanning domains, with a pore forming region bretween transmembrane domains 5 and 6
	a C terminal cytoplasmic tail

HOMOLOGY

interspecies

homolog to murine Trpv3

intraspecies

homolog to TRPV1,TRPV4

Homologene

FAMILY	TRPV family (vanillo
	d channel family)

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in the formation of heteromeric vanilloid receptor channels, that underlie the thermal hypersensivity of sensory neurons at site of tissue injury
	TRPV3, rather than TRPV4, mainly participates in transmission of warm temperature information from keratinocytes to adjacent nerve endings through ATP release
	present in absorptive cells in the distal colon and may be involved in a variety of cellular functions
	involved in behavioral responses to innocuous and noxious heat
	required for the formation of the skin barrier by regulating the activities of transglutaminases, a family of Ca(2+)-dependent crosslinking enzymes essential for keratinocyte cornification
	heat-activated transient receptor potential ion channel expressed in keratinocytes, inducing nitric oxide production via a nitrite-dependent pathway
	TRPV3 and nitrite are involved in wound healing and thermosensory behaviours
	plays essential roles in skin keratinization, hair growth, and possibly itching sensation
	role of TRPV3 as a strong modulator of cutaneous vascular thermoregulatory mechanisms (
	roles for TMEM79 and TRPV3 in thermosensation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	TRPV1 (contributing to TRPV1 response)
	TRPV3 regulatory region is a target for MBTPS2
	TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of CALCA peptide and nitric oxide in response to local heating of the skin (
	TMEM79 modulated TRPV3 translocalization and promoted its degradation in the lysosomes

cell & other

REGULATION

activated by

Farnesyl Pyrophosphate

inhibited by	Ca2+ from both the extracellular and intracellular sides

Other

thermosensitive ion channel, but capsaicin insensitive

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in injured brachial plexus nerves

Susceptibility

Variant & Polymorphism

Candidate gene	good candidate for future therapy in skin inflammation and pruritus
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   targeting TRPV3 could provide therapeutic potential for keratinization or itching-related skin disorders.

ANIMAL & CELL MODELS

	mutation of TRPV3 is linked to defective hair growth and dermatitis in rodents
	mice lacking the Trpv3 gene also exhibit wavy hair coat and curly whiskers