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FLASH GENE
Symbol TRPV3 contributors: mct - updated : 21-03-2018
HGNC name transient receptor potential cation channel, subfamily V, member 3
HGNC id 18084
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four ankyrin domains at the N terminus, and a critical CaM-binding site with an essential aspartic acid at the pore loop that contribute to the sensitization of TRPV3
  • six transmembrane spanning domains, with a pore forming region bretween transmembrane domains 5 and 6
  • a C terminal cytoplasmic tail
    • HOMOLOGY
    interspecies homolog to murine Trpv3
    intraspecies homolog to TRPV1,TRPV4
    Homologene
    FAMILY TRPV family (vanillo
    d channel family)
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the formation of heteromeric vanilloid receptor channels, that underlie the thermal hypersensivity of sensory neurons at site of tissue injury
  • TRPV3, rather than TRPV4, mainly participates in transmission of warm temperature information from keratinocytes to adjacent nerve endings through ATP release
  • present in absorptive cells in the distal colon and may be involved in a variety of cellular functions
  • involved in behavioral responses to innocuous and noxious heat
  • required for the formation of the skin barrier by regulating the activities of transglutaminases, a family of Ca(2+)-dependent crosslinking enzymes essential for keratinocyte cornification
  • heat-activated transient receptor potential ion channel expressed in keratinocytes, inducing nitric oxide production via a nitrite-dependent pathway
  • TRPV3 and nitrite are involved in wound healing and thermosensory behaviours
  • plays essential roles in skin keratinization, hair growth, and possibly itching sensation
  • role of TRPV3 as a strong modulator of cutaneous vascular thermoregulatory mechanisms (
  • roles for TMEM79 and TRPV3 in thermosensation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRPV1 (contributing to TRPV1 response)
  • TRPV3 regulatory region is a target for MBTPS2
  • TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of CALCA peptide and nitric oxide in response to local heating of the skin (
  • TMEM79 modulated TRPV3 translocalization and promoted its degradation in the lysosomes
    • cell & other
    REGULATION
    activated by Farnesyl Pyrophosphate
    inhibited by Ca2+ from both the extracellular and intracellular sides
    Other thermosensitive ion channel, but capsaicin insensitive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in injured brachial plexus nerves
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • good candidate for future therapy in skin inflammation and pruritus
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    targeting TRPV3 could provide therapeutic potential for keratinization or itching-related skin disorders.
    ANIMAL & CELL MODELS
  • mutation of TRPV3 is linked to defective hair growth and dermatitis in rodents
  • mice lacking the Trpv3 gene also exhibit wavy hair coat and curly whiskers