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FLASH GENE
Symbol TPD52 contributors: mct/pgu - updated : 08-01-2013
HGNC name tumor protein D52
HGNC id 12005
Location 8q21.13      Physical location : 80.947.104 - 81.083.836
Synonym name
  • prostate and colon associated protein
  • prostate leucine zipper
  • identical sequences N8 (24kDa), D52 (20kDa), overexpressed in carcinomas
  • protein N8
  • PC1/MRPS28 fusion protein
    • Synonym symbol(s) D52, N8L, PC-1, PrLZ, hD52, OESC, CRHSP-28
    DNA
    TYPE functioning gene
    STRUCTURE 136.73 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • 5kb promoter maintains the prostate-specific transcription and contains an androgen response element (ARE) that mediates transactivation in response to androgen
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing may contribute to abnormally enhanced levels in prostate cancer (WPMID: 19732746)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4250 - 224 - 2006 16631610
  • isoform 1
    • 8 - 4035 - 207 - 2006 16631610
  • isoform 2
    • 6 - 3966 19.8 184 - 2006 16631610
  • isoform 3
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon moderately
     pancreas exocrine   highly Homo sapiens
    Endocrinepancreas   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
    Reproductivefemale systemplacenta  moderately
     male systemprostate  predominantly
    Respiratorylung   lowly
    Urinarykidney   highly
    cell lineage
    cell lines breast cell carcinomas, prostate cell carcinoma, colon, pancreas, kidney tumor cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lower levels in fetal brain and kidney than in adult
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PEST motif
  • potential glycosylation site
  • several phosphorylation sites
  • a C terminal coiled-coil domain that mediates homomeric and heteromeric interactions among family members
    • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Tpd52 (90.5pc)
    intraspecies homolog to N type calcium channels
    paralog to TP52L1,TP52L2
    Homologene
    FAMILY
  • TPD52 family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • highly charged, acidic, cytosolic and peripheral membrane protein
    • basic FUNCTION
  • molecular marker in ovarian cancer
  • prostate-specific and androgen-responsive gene amplified in prostate cancer
  • promotes cell proliferation and survival during prostate cancer development and progression
  • expression is associated with the progression of prostate cancer LNCaP cells and with androgen signals
  • plays an important role in various molecular events, in the morphological diversification and dissemination of prostate carcinoma cells
  • directly regulates LAMP1 exocytosis in a phosphorylation-dependent manner
  • its phosphorylation plays an important role in the vesicle trafficking events that direct cell abscission
  • Ca2+-dependent phosphorylation at serine 136 plays a mechanistic role in regulating VAMP8-positive endosomal vesicle trafficking necessary for cell abscission during cytokinesis
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • hemodimerizing or heterodimerizing with other TPD52 proteins
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ binding
    • protein
  • interacting with 14-3-3 proteins
  • interacting with TPD52L1
  • interact with MAL2, an integral membrane protein localized to lipid rafts in epithelial cells, annexin VI, synaptobrevin 2 and syntaxin 1
  • MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma
  • PLP2 and RAB5C are novel TPD52 binding partners
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast carcinoma
    tumoral     --over  
    in prostate carcinoma
    tumoral     --over  
    overexpressed in testicular germ cell tumours
    tumoral     --over  
    significantly up-regulated in colorectal cancers
    tumoral     --over  
    TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential biomarker for prostate cancer
    colorectal cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    regulatory sequence that may be used to restrict expression of therapeutic genes to prostate cancer in the prostate cancer gene therapy
    ANIMAL & CELL MODELS