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FLASH GENE

Symbol

TPD52

contributors: mct/pgu - updated : 08-01-2013

HGNC name	tumor protein D52
HGNC id	12005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive intestine small intestine     highly   intestine large intestine colon   moderately   pancreas exocrine       highly Homo sapiens Endocrine pancreas       highly Lymphoid/Immune lymph node       highly Nervous brain       highly Reproductive female system placenta     moderately   male system prostate     predominantly Respiratory lung       lowly Urinary kidney       highly

cell lineage
cell lines	breast cell carcinomas, prostate cell carcinoma, colon, pancreas, kidney tumor cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	lower levels in fetal brain and kidney than in adult

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	PEST motif
	potential glycosylation site
	several phosphorylation sites
	a C terminal coiled-coil domain that mediates homomeric and heteromeric interactions among family members

conjugated

PhosphoP

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

homolog to rattus Tpd52 (90.5pc)

intraspecies	homolog to N type calcium channels
	paralog to TP52L1,TP52L2

Homologene

FAMILY

TPD52 family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
text	highly charged, acidic, cytosolic and peripheral membrane protein

basic FUNCTION	molecular marker in ovarian cancer
	prostate-specific and androgen-responsive gene amplified in prostate cancer
	promotes cell proliferation and survival during prostate cancer development and progression
	expression is associated with the progression of prostate cancer LNCaP cells and with androgen signals
	plays an important role in various molecular events, in the morphological diversification and dissemination of prostate carcinoma cells
	directly regulates LAMP1 exocytosis in a phosphorylation-dependent manner
	its phosphorylation plays an important role in the vesicle trafficking events that direct cell abscission
	Ca2+-dependent phosphorylation at serine 136 plays a mechanistic role in regulating VAMP8-positive endosomal vesicle trafficking necessary for cell abscission during cytokinesis

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

hemodimerizing or heterodimerizing with other TPD52 proteins

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+ binding

protein	interacting with 14-3-3 proteins
	interacting with TPD52L1
	interact with MAL2, an integral membrane protein localized to lipid rafts in epithelial cells, annexin VI, synaptobrevin 2 and syntaxin 1
	MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma
	PLP2 and RAB5C are novel TPD52 binding partners

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in breast carcinoma tumoral     --over   in prostate carcinoma tumoral     --over   overexpressed in testicular germ cell tumours tumoral     --over   significantly up-regulated in colorectal cancers tumoral     --over   TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for prostate cancer
	colorectal cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate regulatory sequence that may be used to restrict expression of therapeutic genes to prostate cancer in the prostate cancer gene therapy

ANIMAL & CELL MODELS