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FLASH GENE
Symbol THPO contributors: mct/npt/pgu - updated : 28-03-2012
HGNC name thrombopoietin
HGNC id 11795
Corresponding disease
THPO thrombocythemia, essential
Location 3q27      Physical location : 184.089.772 - 184.095.932
Synonym name
  • myeloproliferative leukemia virus oncogene ligand
  • megakaryocyte growth and development factor
  • megakaryocyte colony-stimulating factor
  • myeloproliferative leukemia virus oncogene ligand
  • c-mpl ligand
  • Synonym symbol(s) HEMGF, MGDF, MGC163194, MKCSF, ML, MPLLG, TPO
    DNA
    TYPE functioning gene
    STRUCTURE 6.16 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter P1a, upstream of exon 1a, and promoter P1, upstream of exon 1.
    MAPPING cloned Y linked N status confirmed
    Map cen - EVI1 - THPO THPO - qter
    Physical map
    LOC391598 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC391599 3 similar to cytochrome P450 2P1 ABCC5 3q27 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 LOC389179 3 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HTR3D 3q27.3 5-hydroxytryptamine receptor 3 subunit D HTR3C 3q27.3 5-hydroxytryptamine receptor 3 subunit C LOC389180 3 similar to 5-hydroxytryptamine receptor 3 subunit C HTR3E 3q27.3 5-hydroxytryptamine serotonin receptor 3E LOC285244 3q27.3 similar to Heat shock protein HSP 90-alpha (HSP 86) EIF2B5 3q27 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa DVL3 3q27 dishevelled, dsh homolog 3 (Drosophila) LOC389181 3 hypothetical gene supported by U14990; U14992; NM_001005 AP2M1 3q28 adaptor-related protein complex 2, mu 1 subunit ABCF3 3q25-q25.2 ATP-binding cassette, sub-family F (GCN20), member 3 LOC90113 3q27.3 hypothetical protein BC009862 ALG3 3q27.3 asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase) MGC2408 3q27.3 hypothetical protein MGC2408 CAM-KIIN 3q27.3 CaM-KII inhibitory protein ECE2 3q27q28 endothelin converting enzyme 2 PSMD2 3q27.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 EIF4G1 3q27-qter eukaryotic translation initiation factor 4 gamma, 1 MGC21688 3q27.3 hypothetical protein MGC21688 CLCN2 3q27-q28 chloride channel 2 POLR2H 3q28 polymerase (RNA) II (DNA directed) polypeptide H THPO 3q27-q28 thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) CHRD 3q27 chordin LOC285248 3q27.3 hypothetical LOC285248 LOC391600 3 similar to RIKEN cDNA 2310042E22 EPHB3 3q21-qter EphB3 MAGEF1 3q13 EphB3 LOC389182 3 LOC389182 KIAA0804 3q28 LOC389182
    RNA
    TRANSCRIPTS type messenger
    text several alternative splicing products that differ from the full-length protein in its 5' UTR, N- or C-terminal regions
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1788 - 319 - 1995 7849319
    6 - 1793 - 349 - 1995 7849319
    6 - 1805 - 353 - 1995 7849319
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver, spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • EPO/TPO family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulator of platelet formation and involved in megakaryocyte growth
  • important growth factor for the megakaryocyte lineage, controlling its proliferation and differentiation
  • playing a proapoptotic role in the brain and contributing to the timing of neuronal selection by the neurotrophins
  • hematopoietic growth factor regulating platelet production
  • via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity
  • activates a number of secondary messengers that promote cell survival, proliferation and differentiation
  • negatively modulates cardiac inotropy and contributes to the myocardial depressing activity of septic shock serum
  • having ability to stimulate platelet production
  • potential role as a physiological regulator of coronary flow
  • with its receptor MPL are essential in the regulation of the hematopoietic stem and progenitors cells as well as for the differentiation of megakaryocytes into mature platelets
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hematopoietic growth factor (MPL ligand)
  • TENC1 is an important new mediator in THPO/MPL pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THPO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS