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FLASH GENE

Symbol

THPO

contributors: mct/npt/pgu - updated : 28-03-2012

HGNC name	thrombopoietin
HGNC id	11795

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	THPO thrombocythemia, essential
Location	3q27      Physical location : 184.089.772 - 184.095.932
Synonym name	myeloproliferative leukemia virus oncogene ligand
	megakaryocyte growth and development factor
	megakaryocyte colony-stimulating factor
	myeloproliferative leukemia virus oncogene ligand
	c-mpl ligand
Synonym symbol(s)	HEMGF, MGDF, MGC163194, MKCSF, ML, MPLLG, TPO

DNA

TYPE	functioning gene
STRUCTURE	6.16 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	promoter P1a, upstream of exon 1a, and promoter P1, upstream of exon 1.

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - EVI1 - THPO THPO - qter

RNA

TRANSCRIPTS	type	messenger

text	several alternative splicing products that differ from the full-length protein in its 5' UTR, N- or C-terminal regions

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001177598 6 - 1788 NP_001171069 - 319 - 1995 7849319 NM_001177597 6 - 1793 NP_001171068 - 349 - 1995 7849319 NM_000460 6 - 1805 NP_000451 - 353 - 1995 7849319

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus       Respiratory respiratory tract larynx

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	liver, spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

EPO/TPO family

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	stimulator of platelet formation and involved in megakaryocyte growth
	important growth factor for the megakaryocyte lineage, controlling its proliferation and differentiation
	playing a proapoptotic role in the brain and contributing to the timing of neuronal selection by the neurotrophins
	hematopoietic growth factor regulating platelet production
	via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity
	activates a number of secondary messengers that promote cell survival, proliferation and differentiation
	negatively modulates cardiac inotropy and contributes to the myocardial depressing activity of septic shock serum
	having ability to stimulate platelet production
	potential role as a physiological regulator of coronary flow
	with its receptor MPL are essential in the regulation of the hematopoietic stem and progenitors cells as well as for the differentiation of megakaryocytes into mature platelets

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	hematopoietic growth factor (MPL ligand)
	TENC1 is an important new mediator in THPO/MPL pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

THPO

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS