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GENATLAS PHENOTYPE

last update : 29/06/2006

Symbol	EVI1
Location	3q26.2
Name	myelodysplastic syndrome
Corresponding gene	MECOM
Main clinical features	related to therapy, acute myeloid or undifferentiated leukemia, blastic crisis in CML with inversion inv3(q21;q26), translocations t(3;3)(q21;q26), t(3;12)(q26;p13), t(3;21)(q26;q22), der 3t(3;78) and others (see also MDS1, EAP, ETV6, GR6, AML1, RPN1, TCRBV@)
Genetic determination
Function/system disorder	hematology
Type	malignancy

Gene product

Name	chimeric fusion protein 5'- AML1 - EVI1 -3', or 5' - AML1 - MDS1/EVI1 - 3'

Remark(s)