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FLASH GENE

Symbol

SLC2A5

contributors: mct - updated : 18-03-2020

HGNC name	solute carrier family 2 (facilitated glucose/fructose transporter), member 5
HGNC id	11010

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.23      Physical location : 9.097.006 - 9.148.510
Synonym name	glucose transporter-like protein 5
Synonym symbol(s)	GLUT5, D1S274E, GLUT-5

DNA

TYPE	functioning gene
STRUCTURE	37.15 kb     12 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D1S1615 - D1S3275 - D1S503 - D1S1465 - D1S2068E - SLC2A5 - CA6 - D1S160 - ENO1 - D1S2213 - D1S3675 - D1S1635 - cen
Authors	White (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001328619 13 - 4255 NP_001315548 - 501 - 2018 29913554 NM_001328620 12 - 4047 NP_001315549 - 457 - 2018 29913554 NM_001328621 9 - 3700 NP_001315550 - 354 - 2018 29913554 NM_003039 12 - 4085 NP_003030 - 501 - 2018 29913554 NM_001135585 5 - 2375 NP_001129057 - 244 - 2018 29913554

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Homo sapiens Nervous plexus choroid         Homo sapiens Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Muscular striatum skeletal     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous ependymal cell Homo sapiens Nervous epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve putative transmembrane segments (12TM)
	intracellular N and C termini
	a large extracellular loop with a glycosylation site between TM1 and 2,
	a small and a large intracellular loops, respectively between TM2 and 3 and TM8 and 9, both with the conserved RXGRR motif

HOMOLOGY

Homologene

FAMILY

solute carrier family 2

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	basal membrane of enterocytes

basic FUNCTION	facilitated glucose transporter
	cytochalasin b-sensitive carrier, may be functioning primarily as a fructose transporter
	fructose-induced hypertension is likely caused by increased salt absorption by the intestine and kidney and the transporters SLC26A6 and SLC2A5 are essential in this process
	SLC2A5 is essential for the absorption of fructose in the intestine and plays a fundamental role in the generation of fructose-induced hypertension
	role for the GLUT5 isoform in fructose uptake that takes place in cRCC cells and which subsequently leads to the malignant RCC progression
	fructose and SLC2A5 play an important role in regulating adipose differentiation
	altered activity of the fructose transporter GLUT5, an isoform of the facilitated-diffusion glucose transporter family, has been linked to disorders such as type 2 diabetes and obesity
	major transporter of fructose
	is the major fructose transporter which mediates most of fructose uptake in cells
	is required for intestinal fructose absorption

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

direct interaction of MLXIPL with the SLC2A5 promoter, but not the SLC9A3 promoter, in the small intestine

cell & other

REGULATION

activated by

thyroid hormones

induced by

insulin responsive

Other

regulated by NR1H3

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	SLC2A5 with SLC2A10, and SLC2A13, are potential prognostic biomarkers in acute myeloid leukemia
Therapy target
	System Type Disorder Pubmed cancer urinary   therapeutic potential for targeting the metabolic pathway of SLC2A5 against clear cell renal cell carcinoma cancer hemopathy   targeting SLC2A5 might be promising in B-ALL treatment, especially for Ph+ALL patients with high SLC2A5 expression

ANIMAL & CELL MODELS