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FLASH GENE
Symbol SLC26A8 contributors: mct - updated : 03-04-2012
HGNC name solute carrier family 26, member 8
HGNC id 14468
Location 6p21.31      Physical location : 35.911.291 - 35.992.413
Synonym name
  • anion transporter/exchanger 8
  • testis anion transporter 1
  • Synonym symbol(s) TAT1, FLJ32714
    DNA
    TYPE functioning gene
    STRUCTURE 81.12 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391916 6 hypothetical gene supported by BC001032; NM_001014 SNRPC 6p21.2 small nuclear ribonucleoprotein polypeptide C C6orf107 6p21 chromosome 6 open reading frame 107 TAF11 6p21 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa ANKS1 6p21.31 ankyrin repeat and SAM domain containing 1 TCP11 6p21.2 t-complex 11 (mouse) CEGF3 6p21.3 CUB domain and EGF-like repeat containing 3 ZNF76 6p21.2 zinc finger protein 76 (expressed in testis) DEF6 6p21.33-p21.1 differentially expressed in FDCP 6 homolog (mouse) PPARD 6p21.2-p21.1 peroxisome proliferative activated receptor, delta MKRNP2 6p21.1 makorin, ring finger protein, pseudogene 2 FANCE 6p22-p21 Fanconi anemia, complementation group E RPL10A 6p21.3 ribosomal protein L10a TEAD3 6p21.2 TEA domain family member 3 TULP1 6p21.3 tubby like protein 1 LOC389382 6 similar to Rps15a protein FKBP5 6p21.3-p21.2 FK506 binding protein 5 C6orf81 6p21.31 chromosome 6 open reading frame 81 LOC389383 6 similar to AAAL3045 LOC340204 6p21.31 similar to precursor peptide CLPS 6p22-p21.1 colipase, pancreatic MGC33835 6p21.31 hypothetical protein MGC33835 SRPK1 6p213-p21.2 SFRS protein kinase 1 SLC26A8 6p21 solute carrier family 26, member 8 MAPK14 6p21.2 mitogen-activated protein kinase 14 MAPK13 6p21.1 mitogen-activated protein kinase 13 BRPF3 6p21 bromodomain and PHD finger containing, 3 PNPLA1 6p21.31 patatin-like phospholipase domain containing 1 LOC389384 6 similar to RIKEN cDNA 4930539E08 ETV7 6p21 ets variant gene 7 (TEL2 oncogene ) STEPP 6p21.31 small testis-specific peroxisomal protein C6orf69 6p21.31 chromosome 6 open reading frame 69 STK38 6p21 serine/threonine kinase 38 SFRS3 11p15.1 splicing factor, arginine/serine-rich 3 LOC389385 6 similar to Cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) (Proline aminopeptidase) (Prolyl aminopeptidase) LOC389386 6 similar to Cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) (Proline aminopeptidase) (Prolyl aminopeptidase) CDKN1A 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) LOC346190 6p21.31 similar to hypothetical protein FLJ31614 LOC391917 6 similar to putative G-protein coupled receptor CPNE5 6p21.1 copine V PPIL1 6p21.1 peptidylprolyl isomerase (cyclophilin)-like 1 C6orf89 6p21.31 chromosome 6 open reading frame 89 PI16 6p21.31 protease inhibitor 16 MTCH1 6pter-p24.1 mitochondrial carrier homolog 1 (C. elegans) FGD2 6p21.2 FGD1 family, member 2 LOC285849 6p21.31 similar to cytochrome c oxidase subunit VIa polypeptide 1 precursor; cytochrome C oxidase subunit VIa homolog LOC389387 6 similar to 60S ribosomal protein L12
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3434 109 970 - 2002 11834742
    18 - 3157 - 865 - 2002 11834742
    20 - 3410 - 970 - 2002 11834742
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    made of a N and C cytoplasmic termini:
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail
  • a sulfate transporter motif and a relatively hydrophobic region near the C terminus
  • the STAS domain (sulfate transporter and anti-sigma factor antagonist)
  • HOMOLOGY
    interspecies homolog to C.elegans Y48G10A.3
    Homologene
    FAMILY
  • sulfate permease family
  • SLC26 gene family of anion transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sulfate transporter specificially expressed in spermatocytes and spermatids
  • critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
  • role in male fertility, either independently or through interaction and reciprocal regulation with co-localized proteins shown to affect fertility
  • sperm-specific member of the SLC26 family of anion exchangers, associating with the CFTR channel and strongly stimulating its activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SLC26A8-CFTR complex impicated in the regulation of the chloride and bicarbonate fluxes required for sperm motility and capacitation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • male germ cell Rho GTPase (MGCRG)
  • SLC26A8 and CFTR physically interact, and SLC26A8 expression strongly stimulates CFTR activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    heterozygous SLC26A8 missense mutations that abolish functional interaction with the CFTR channel and potentially contribute to subfertility in men by impairing sperm motility and capacitation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in the mouse, deletion of Tat1 caused male sterility due to a lack of sperm motility, impaired sperm capacitation and structural defects of the flagella
  • Tat1 null males mice were sterile due to complete lack of sperm motility and reduced sperm fertilization potential (