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FLASH GENE

Symbol

SLC26A8

contributors: mct - updated : 10-02-2021

HGNC name	solute carrier family 26, member 8
HGNC id	14468

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system testis     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens Reproductive spermatocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	made of a N and C cytoplasmic termini:
	twelve transmembrane segments (12TM)
	a large cytoplasmic tail
	a sulfate transporter motif and a relatively hydrophobic region near the C terminus
	the STAS domain (sulfate transporter and anti-sigma factor antagonist)
	multiple N-glycosylation sites in the second extracytosolic (EC) loop

HOMOLOGY

interspecies

homolog to C.elegans Y48G10A.3

Homologene

FAMILY	sulfate permease family
	SLC26 gene family of anion transporters

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	localized the proteins to the plasma membrane and the endoplasmic reticulum

basic FUNCTION	sulfate transporter specificially expressed in spermatocytes and spermatids
	critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
	role in male fertility, either independently or through interaction and reciprocal regulation with co-localized proteins shown to affect fertility
	sperm-specific member of the SLC26 family of anion exchangers, associating with the CFTR channel and strongly stimulating its activity
	contribute to the composition and the pH regulation of the secreted fluids

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

SLC26A8-CFTR complex impicated in the regulation of the chloride and bicarbonate fluxes required for sperm motility and capacitation

INTERACTION

DNA

RNA

small molecule

protein	male germ cell Rho GTPase (MGCRG)
	SLC26A8 and CFTR physically interact, and SLC26A8 expression strongly stimulates CFTR activity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       heterozygous SLC26A8 missense mutations that abolish functional interaction with the CFTR channel and potentially contribute to subfertility in men by impairing sperm motility and capacitation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	in the mouse, deletion of Tat1 caused male sterility due to a lack of sperm motility, impaired sperm capacitation and structural defects of the flagella
	Tat1 null males mice were sterile due to complete lack of sperm motility and reduced sperm fertilization potential (