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FLASH GENE
Symbol SLC26A8 contributors: mct - updated : 10-02-2021
HGNC name solute carrier family 26, member 8
HGNC id 14468
ASSOCIATED DISORDERS
corresponding disease(s) SPGF3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
heterozygous SLC26A8 missense mutations that abolish functional interaction with the CFTR channel and potentially contribute to subfertility in men by impairing sperm motility and capacitation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • in the mouse, deletion of Tat1 caused male sterility due to a lack of sperm motility, impaired sperm capacitation and structural defects of the flagella
  • Tat1 null males mice were sterile due to complete lack of sperm motility and reduced sperm fertilization potential (