Symbol
| SLC26A8
| contributors: mct - updated : 10-02-2021
|
HGNC name
| solute carrier family 26, member 8
|
HGNC id
| 14468
|
corresponding disease(s)
|
SPGF3
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
| germinal mutation
|  
|  
|  
|
heterozygous SLC26A8 missense mutations that abolish functional interaction with the CFTR channel and potentially contribute to subfertility in men by impairing sperm motility and capacitation | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| in the mouse, deletion of Tat1 caused male sterility due to a lack of sperm motility, impaired sperm capacitation and structural defects of the flagella | |
Tat1 null males mice were sterile due to complete lack of sperm motility and reduced sperm fertilization potential ( |