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FLASH GENE
Symbol SLC26A8 contributors: mct - updated : 10-02-2021
HGNC name solute carrier family 26, member 8
HGNC id 14468
DNA
TYPE functioning gene
STRUCTURE 81.12 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3434 109 970 - 2002 11834742
18 - 3157 - 865 - 2002 11834742
20 - 3410 - 970 - 2002 11834742
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductivespermatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
made of a N and C cytoplasmic termini:
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail
  • a sulfate transporter motif and a relatively hydrophobic region near the C terminus
  • the STAS domain (sulfate transporter and anti-sigma factor antagonist)
  • multiple N-glycosylation sites in the second extracytosolic (EC) loop
  • HOMOLOGY
    interspecies homolog to C.elegans Y48G10A.3
    Homologene
    FAMILY
  • sulfate permease family
  • SLC26 gene family of anion transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localized the proteins to the plasma membrane and the endoplasmic reticulum
  • basic FUNCTION
  • sulfate transporter specificially expressed in spermatocytes and spermatids
  • critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
  • role in male fertility, either independently or through interaction and reciprocal regulation with co-localized proteins shown to affect fertility
  • sperm-specific member of the SLC26 family of anion exchangers, associating with the CFTR channel and strongly stimulating its activity
  • contribute to the composition and the pH regulation of the secreted fluids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SLC26A8-CFTR complex impicated in the regulation of the chloride and bicarbonate fluxes required for sperm motility and capacitation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • male germ cell Rho GTPase (MGCRG)
  • SLC26A8 and CFTR physically interact, and SLC26A8 expression strongly stimulates CFTR activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    heterozygous SLC26A8 missense mutations that abolish functional interaction with the CFTR channel and potentially contribute to subfertility in men by impairing sperm motility and capacitation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in the mouse, deletion of Tat1 caused male sterility due to a lack of sperm motility, impaired sperm capacitation and structural defects of the flagella
  • Tat1 null males mice were sterile due to complete lack of sperm motility and reduced sperm fertilization potential (