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FLASH GENE
Symbol SHBG contributors: mct/npt - updated : 30/10/2008
HGNC name sex hormone-binding globulin
HGNC id 10839
Location 17p13.1      Physical location : 7.517.381 - 7.536.700
Synonym name
  • androgen binding protein
  • testosterone-estrogen-binding globulin
  • testis-specific androgen-binding protein
  • sex steroid-binding protein
  • Synonym symbol(s) ABP, MGC126834, MGC138391, TEBG, SBP
    DNA
    TYPE functioning gene
    STRUCTURE 3.18 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked Y status confirmed
    Physical map
    ZBTB4 17p13.2 zinc finger and BTB domain containing 4 POLR2A 17p13.1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa TNFSF12 17p13.1 tumor necrosis factor (ligand) superfamily, member 12 TNFSF13 17p13.1 tumor necrosis factor (ligand) superfamily, member 13 SENP3 17p13 tumor necrosis factor (ligand) superfamily, member 13 EIF4A1 17p13.1 eukaryotic translation initiation factor 4A, isoform 1 CD68 17p13.1 CD68 antigen MPDU1 17p13.1-p12 mannose-P-dolichol utilization defect 1 SOX15 17p12.3 SRY (sex determining region Y)-box 15 FXR2 17p13.1 fragile X mental retardation, autosomal homolog 2 SAT2 17p13.2 spermidine/spermine N1-acetyltransferase 2 SHBG 17p13.1 sex hormone-binding globulin ATP1B2 17p13.1 ATPase, Na+/K+ transporting, beta 2 polypeptide TP53 17p13.1 tumor protein p53 (Li-Fraumeni syndrome) FLJ10385 17p13.2 hypothetical protein FLJ10385 EFNB3 17p13.1-p11.2 ephrin-B3 LOC284158 17p13.2 similar to KIAA1503 protein
    RNA
    TRANSCRIPTS type messenger
    text with two alternative products
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1209 43.8 402 - Gershagen, Power (1992)
    - initiation site 1600 41.5 381 in the acrosome during the spermatogenesis Hammond,Selva
    remains within a cellular compartment and binding steroid ligand with high affinity
    - initiation site 1005 31.4 288 testis,liver Hammond,Gershagen
    alternative exon 1 different truncated form,lacking exon 7 (part of steroid binding domain)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
     male systemprostate   
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    ReproductiveSertoli cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two laminin A/neurexin/sex hormone-binding globulin repeats (LNS)
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • laminin G family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text intracellular during spermatogenesis
    basic FUNCTION
  • regulating the free concentration of estrogens or steroids that bind to it
  • internalized by brain cells, which may be affected by the presence of ER beta
  • modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer
  • playing a role in the aetiology of type 2 diabetes (Perry 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SHBG receptor in prostate stromal and epithelial cells
  • binding estradiol and testosterone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    elevated SHBG levels may cause increased bone mass
    Susceptibility
  • to variation of age of menarche
  • to variation of hip BMD in men
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • association of a functional (TAAAA)n polymorphism in the promoter with the timing of menarche
  • polymorphisms in the promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men
  • SNP rs1799941 was associated with type 2 diabetes (Perry 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS