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FLASH GENE
Symbol SHBG contributors: mct/npt - updated : 30/10/2008
HGNC name sex hormone-binding globulin
HGNC id 10839
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two laminin A/neurexin/sex hormone-binding globulin repeats (LNS)
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • laminin G family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text intracellular during spermatogenesis
    basic FUNCTION
  • regulating the free concentration of estrogens or steroids that bind to it
  • internalized by brain cells, which may be affected by the presence of ER beta
  • modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer
  • playing a role in the aetiology of type 2 diabetes (Perry 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SHBG receptor in prostate stromal and epithelial cells
  • binding estradiol and testosterone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    elevated SHBG levels may cause increased bone mass
    Susceptibility
  • to variation of age of menarche
  • to variation of hip BMD in men
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • association of a functional (TAAAA)n polymorphism in the promoter with the timing of menarche
  • polymorphisms in the promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men
  • SNP rs1799941 was associated with type 2 diabetes (Perry 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS