Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol SHBG contributors: mct/npt - updated : 31-05-2023
HGNC name sex hormone-binding globulin
HGNC id 10839
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
elevated SHBG levels may cause increased bone mass
constitutional     --over  
higher circulating SHBG levels were directly and independently predictive of lower coronary heart disease (CHD) risk in both men and women
  • to variation of age of menarche
  • to variation of hip BMD in men
  • to type 2 diabetes
  • to variation of testosterone level
  • to Polycystic ovary syndrome (PCOS)
  • Variant & Polymorphism SNP , other
  • association of a functional (TAAAA)n polymorphism in the promoter with the timing of menarche
  • polymorphisms in the promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men
  • SNP rs1799941 was associated with type 2 diabetes (Perry 2010)
  • rs727428 was the most significant variant at 17p13 associated with T and DHT levels
  • SHBG gene polymorphism is correlated with the risk of PCOS
  • Candidate gene
  • role for SHBG as PCOS candidate gene
  • Marker
  • SHBG levels may prove to be a useful biomarker for the diagnosis and treatment of PCOS
  • Therapy target
    diabetetype 2 
    development of SHBG-raising therapies is a means to prevent or treat disorders such as type 2 diabetes