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FLASH GENE
Symbol SHBG contributors: mct/npt - updated : 30/10/2008
HGNC name sex hormone-binding globulin
HGNC id 10839
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
elevated SHBG levels may cause increased bone mass
Susceptibility
  • to variation of age of menarche
  • to variation of hip BMD in men
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • association of a functional (TAAAA)n polymorphism in the promoter with the timing of menarche
  • polymorphisms in the promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men
  • SNP rs1799941 was associated with type 2 diabetes (Perry 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS