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FLASH GENE

Symbol

SHBG

contributors: mct/npt - updated : 31-05-2023

HGNC name	sex hormone-binding globulin
HGNC id	10839

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   elevated SHBG levels may cause increased bone mass constitutional     --over   higher circulating SHBG levels were directly and independently predictive of lower coronary heart disease (CHD) risk in both men and women

Susceptibility

to variation of age of menarche to variation of hip BMD in men to type 2 diabetes to variation of testosterone level to Polycystic ovary syndrome (PCOS)

Variant & Polymorphism SNP , other	association of a functional (TAAAA)n polymorphism in the promoter with the timing of menarche
	polymorphisms in the promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men
	SNP rs1799941 was associated with type 2 diabetes (Perry 2010)
	rs727428 was the most significant variant at 17p13 associated with T and DHT levels
	SHBG gene polymorphism is correlated with the risk of PCOS

Candidate gene	role for SHBG as PCOS candidate gene
Marker	SHBG levels may prove to be a useful biomarker for the diagnosis and treatment of PCOS
Therapy target
	System Type Disorder Pubmed diabete type 2   development of SHBG-raising therapies is a means to prevent or treat disorders such as type 2 diabetes

ANIMAL & CELL MODELS