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FLASH GENE
Symbol SHBG contributors: mct/npt - updated : 30/10/2008
HGNC name sex hormone-binding globulin
HGNC id 10839
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivemale systemtestis   
 male systemprostate   
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
ReproductiveSertoli cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two laminin A/neurexin/sex hormone-binding globulin repeats (LNS)
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • laminin G family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text intracellular during spermatogenesis
    basic FUNCTION
  • regulating the free concentration of estrogens or steroids that bind to it
  • internalized by brain cells, which may be affected by the presence of ER beta
  • modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer
  • playing a role in the aetiology of type 2 diabetes (Perry 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SHBG receptor in prostate stromal and epithelial cells
  • binding estradiol and testosterone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    elevated SHBG levels may cause increased bone mass
    Susceptibility
  • to variation of age of menarche
  • to variation of hip BMD in men
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • association of a functional (TAAAA)n polymorphism in the promoter with the timing of menarche
  • polymorphisms in the promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men
  • SNP rs1799941 was associated with type 2 diabetes (Perry 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS