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FLASH GENE
Symbol SEPSECS contributors: mct - updated : 26-10-2010
HGNC name Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
HGNC id 30605
Corresponding disease
CBLCA cerebellocerebral atrophy, progressive
Location 4p15.2      Physical location : 25.121.627 - 25.162.204
Synonym name
  • soluble liver and pancreas antigen
  • selenocysteine synthase
  • UGA suppressor tRNA-associated protein
  • Sec synthase
  • soluble liver antigen
  • UGA suppressor tRNA-associated protein
  • SLA/LP autoantigen
  • O-phosphoseryl-tRNA
  • soluble liver antigen
  • Synonym symbol(s) SLA/LP, SLA, SLA-p35, TRNP48, MGC161491, DKFZp434B1417
    EC.number 2.9.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 28.26 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 5645 - 501 - 2000 10801173
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to tRNP (Ser) Sec
    Homologene
    FAMILY
  • fold type I PLP enzyme family
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be a UGA-suppressor tRNA-associated protein
  • role of TRNAU1AP and SEPSECS in selenoprotein biosynthesis through interaction with tRNA([Ser]Sec) in a multiprotein complex
  • catalyzes the conversion of Sep-tRNA to Sec-tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRNAU1AP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CBLCA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    autoimmune hepatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS