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FLASH GENE

Symbol

SEPSECS

contributors: mct - updated : 26-10-2010

HGNC name	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
HGNC id	30605

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CBLCA cerebellocerebral atrophy, progressive
Location	4p15.2      Physical location : 25.121.627 - 25.162.204
Synonym name	soluble liver and pancreas antigen
	selenocysteine synthase
	UGA suppressor tRNA-associated protein
	Sec synthase
	soluble liver antigen
	UGA suppressor tRNA-associated protein
	SLA/LP autoantigen
	O-phosphoseryl-tRNA
	soluble liver antigen
Synonym symbol(s)	SLA/LP, SLA, SLA-p35, TRNP48, MGC161491, DKFZp434B1417
EC.number	2.9.1.2

DNA

TYPE	functioning gene
STRUCTURE	28.26 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016955 11 - 5645 NP_058651 - 501 - 2000 10801173

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage
cell lines
fluid/secretion	serum

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to tRNP (Ser) Sec

Homologene

FAMILY

fold type I PLP enzyme family

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	may be a UGA-suppressor tRNA-associated protein
	role of TRNAU1AP and SEPSECS in selenoprotein biosynthesis through interaction with tRNA([Ser]Sec) in a multiprotein complex
	catalyzes the conversion of Sep-tRNA to Sec-tRNA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with TRNAU1AP

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CBLCA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         autoimmune hepatitis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS