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FLASH GENE
Symbol SEPSECS contributors: mct - updated : 26-10-2010
HGNC name Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
HGNC id 30605
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 5645 - 501 - 2000 10801173
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to tRNP (Ser) Sec
Homologene
FAMILY
  • fold type I PLP enzyme family
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be a UGA-suppressor tRNA-associated protein
  • role of TRNAU1AP and SEPSECS in selenoprotein biosynthesis through interaction with tRNA([Ser]Sec) in a multiprotein complex
  • catalyzes the conversion of Sep-tRNA to Sec-tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRNAU1AP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CBLCA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    autoimmune hepatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS