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FLASH GENE
Symbol SEPSECS contributors: mct - updated : 26-10-2010
HGNC name Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
HGNC id 30605
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to tRNP (Ser) Sec
Homologene
FAMILY
  • fold type I PLP enzyme family
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be a UGA-suppressor tRNA-associated protein
  • role of TRNAU1AP and SEPSECS in selenoprotein biosynthesis through interaction with tRNA([Ser]Sec) in a multiprotein complex
  • catalyzes the conversion of Sep-tRNA to Sec-tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRNAU1AP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CBLCA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    autoimmune hepatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS