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Symbol RPA1 contributors: mct - updated : 08-12-2009
HGNC name replication protein A1, 70kDa
HGNC id 10289
Location 17p13.3      Physical location : 1.733.272 - 1.802.848
Synonym name
  • G replication protein A,subunit 1
  • RF-A protein 1
  • single-stranded DNA-binding protein
  • Synonym symbol(s) RPA70, REPA1, HSSB, RF-A, RP-A, HSU24186, MGC120333, MGC120334, MST075, MSTP075
    TYPE functioning gene
    STRUCTURE 69.58 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - D17S643 ,(D17S28 , D17S30 ) - RPA1 - PFN1 - SLC2A4 - cen
    Authors Umbricht (94)
    Physical map
    LOC390753 17 similar to putative protein LOC390754 17 similar to hypothetical class II basic helix-loop-helix protein LOST1 17p13.3 located at seventeen-p-thirteen point three 1 YWHAE 17p13.3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide CRK 17p13.3 v-crk sarcoma virus CT10 oncogene homolog (avian) MYO1C 17p13.3-p13.2 myosin IC SKIP 17p13 myosin IC PITPN 17p13.3 phosphotidylinositol transfer protein MGC34680 17p13.3 hypothetical protein MGC34680 RILP 17p13.3 hypothetical protein MGC34680 SCARF1 17p13.3 scavenger receptor class F, member 1 PRPF8 17p13.3 PRP8 pre-mRNA processing factor 8 homolog (yeast) LOC388317 17 LOC388317 MGC14376 17p13.3 hypothetical protein MGC14376 LOC388318 17 LOC388318 FLJ33817 17p13.3 hypothetical protein FLJ33817 SERPINF2 17p13 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 SERPINF1 17p13.3 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 KIAA1936 17p13.3 KIAA1936 protein RPA1 17p13.3 replication protein A1, 70kDa NGRH2 LOC388319 17 LOC388319 DPH2L1 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) OVCA2 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) HIC1 17p13.3 hypermethylated in cancer 1 C17orf31 17p13.3 chromosome 17 open reading frame 31 SRR 17q13.3 serine racemase LOC388320 17 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FLJ10534 17p13.3 hypothetical protein FLJ10534 KIAA0397 17p13.3 hypothetical protein FLJ10534 MNT 17p13.3 MAX binding protein MGC3329 17p13.3 hypothetical protein MGC3329
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4345 68.1 616 - 2008 18245774
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Hearing/Equilibriumear   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage spermatocytes
    cell lines
    at STAGE
  • a N terminal domain involved in protein interaction, critical component of the RPA-MRN protein-protein interaction, DBD-F can interact with ssDNA, with multiple proteins, and may play a role in regulating RPA function upon phosphorylation of RPA2
  • a central DNA-binding domain (composed of two copies of a ss-DNA binding motif)
  • three DNA-binding domains (DBD), DBD-A, DBD-B and DBD-C
  • and a DNA helix-destabilization (unwinding) activity,
  • a zinc finger and a C terminal intersubunit interaction domains
  • mono polymer heteromer , trimer
  • replication factor A protein 1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    text colocalizes with BRIP1 in nuclear foci after DNA damage
    basic FUNCTION
  • essential for DNA replication and thus for progression through S phase
  • colocalizing with RAD51 on synapsed axes in meiosis and facilitating RAD51 function
  • also colocalizing with BLM in meiotic prophase nuclei of spermatocytes
  • involved in processes including replication, recombination, transcription, telomere maintenance, and in regulation of telomerase (essential for homologous recombination and DNA replication)
  • essential for DNA replication, repair, and recombination
  • roles of RPA1, BRIP1, and other DNA helicases in the metabolism of damaged DNA that can interfere with basic cellular processes of DNA metabolism
  • plays a key role in DNA replication and activation of the ATR checkpoint
  • plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in cells
  • proper orientation of XPA and RPA1 in the stage of preincision was achieved in the absence of ERCC3 and XPG
  • with RPA1, and RPA2, plays essential roles in DNA transactions
  • RPA1 and MEIOB, are essential to ensure the proper stabilization of recombinases which is required for successful homology search and meiotic recombination
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair, base excision repair
    nucleotide, repair, nucleotide excision repair
    a component
  • component of a trimeric single strand binding protein of the replication protein A complex, involved in replication, homologous recombination and nucleotide excision repair
  • three subunits: RPA1, RPA2, and RPA3)
    DNA binding
    small molecule
  • RBT1
  • NOS3 repressor of mutated NOS3
  • interacting with XRCC3 and RAD52
  • interaction with WRN or BLM helicases plays an important role in the mechanism for RPA stimulation of helicase-catalyzed DNA unwinding
  • first regulatory partner of BRIP1 (FANCJ) (BRIP1-RPA1 interaction is likely to be important for the role of the helicase to more efficiently unwind DNA repair intermediates to maintain genomic stability
  • direct interaction between RPA1 with both NBS1 and MRE11
  • PAXIP1 and RPA1, both involved in DNA replication and DNA repair, are HLTF-interacting proteins although cells depleted of HLTF did not show defects in cellular responses to DNA damage
  • interacts with the specific proteins among those that play roles in the regulation of the replication fork progression
  • upon replication blockage, WRN and RPA1 functionally interact and cooperate to help properly resolve replication forks and maintain genome stability
  • interacting with DMRT2 (potent inhibitor of the RPA1 displacing activity of HNRNPA1)
  • BID associates with RPA1 and stimulates the recruitment and/or stabilization of ATR-ATRIP to the DNA damage sensor complex
  • recruits UNG to sites of deamination and keeps DNA in a single stranded conformation, thus avoiding error-free base excision repair of the deaminated cytosine
  • ATR signals the accumulation of replication protein A (RPA1)-covered single-stranded DNA (ssDNA), which is caused by replication obstacles.
  • ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA1
  • cell & other