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FLASH GENE
Symbol RPA1 contributors: mct - updated : 08-12-2009
HGNC name replication protein A1, 70kDa
HGNC id 10289
Location 17p13.3      Physical location : 1.733.272 - 1.802.848
Synonym name
  • G replication protein A,subunit 1
  • RF-A protein 1
  • single-stranded DNA-binding protein
    • Synonym symbol(s) RPA70, REPA1, HSSB, RF-A, RP-A, HSU24186, MGC120333, MGC120334, MST075, MSTP075
    DNA
    TYPE functioning gene
    STRUCTURE 69.58 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - D17S643 ,(D17S28 , D17S30 ) - RPA1 - PFN1 - SLC2A4 - cen
    Authors Umbricht (94)
    Physical map
    LOC390753 17 similar to putative protein LOC390754 17 similar to hypothetical class II basic helix-loop-helix protein LOST1 17p13.3 located at seventeen-p-thirteen point three 1 YWHAE 17p13.3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide CRK 17p13.3 v-crk sarcoma virus CT10 oncogene homolog (avian) MYO1C 17p13.3-p13.2 myosin IC SKIP 17p13 myosin IC PITPN 17p13.3 phosphotidylinositol transfer protein MGC34680 17p13.3 hypothetical protein MGC34680 RILP 17p13.3 hypothetical protein MGC34680 SCARF1 17p13.3 scavenger receptor class F, member 1 PRPF8 17p13.3 PRP8 pre-mRNA processing factor 8 homolog (yeast) LOC388317 17 LOC388317 MGC14376 17p13.3 hypothetical protein MGC14376 LOC388318 17 LOC388318 FLJ33817 17p13.3 hypothetical protein FLJ33817 SERPINF2 17p13 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 SERPINF1 17p13.3 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 KIAA1936 17p13.3 KIAA1936 protein RPA1 17p13.3 replication protein A1, 70kDa NGRH2 LOC388319 17 LOC388319 DPH2L1 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) OVCA2 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) HIC1 17p13.3 hypermethylated in cancer 1 C17orf31 17p13.3 chromosome 17 open reading frame 31 SRR 17q13.3 serine racemase LOC388320 17 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FLJ10534 17p13.3 hypothetical protein FLJ10534 KIAA0397 17p13.3 hypothetical protein FLJ10534 MNT 17p13.3 MAX binding protein MGC3329 17p13.3 hypothetical protein MGC3329
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4345 68.1 616 - 2008 18245774
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Hearing/Equilibriumear   highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeye    
    cell lineage spermatocytes
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain involved in protein interaction, critical component of the RPA-MRN protein-protein interaction, DBD-F can interact with ssDNA, with multiple proteins, and may play a role in regulating RPA function upon phosphorylation of RPA2
  • a central DNA-binding domain (composed of two copies of a ss-DNA binding motif)
  • three DNA-binding domains (DBD), DBD-A, DBD-B and DBD-C
  • and a DNA helix-destabilization (unwinding) activity,
  • a zinc finger and a C terminal intersubunit interaction domains
    • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • replication factor A protein 1 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    text colocalizes with BRIP1 in nuclear foci after DNA damage
    basic FUNCTION
  • essential for DNA replication and thus for progression through S phase
  • colocalizing with RAD51 on synapsed axes in meiosis and facilitating RAD51 function
  • also colocalizing with BLM in meiotic prophase nuclei of spermatocytes
  • involved in processes including replication, recombination, transcription, telomere maintenance, and in regulation of telomerase (essential for homologous recombination and DNA replication)
  • essential for DNA replication, repair, and recombination
  • roles of RPA1, BRIP1, and other DNA helicases in the metabolism of damaged DNA that can interfere with basic cellular processes of DNA metabolism
  • plays a key role in DNA replication and activation of the ATR checkpoint
  • plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in cells
  • proper orientation of XPA and RPA1 in the stage of preincision was achieved in the absence of ERCC3 and XPG
  • with RPA1, and RPA2, plays essential roles in DNA transactions (Pubmed 20679368)
    • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair, base excision repair
    nucleotide, repair, nucleotide excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a trimeric single strand binding protein of the replication protein A complex, involved in replication, homologous recombination and nucleotide excision repair
  • three subunits: RPA1, RPA2, and RPA3)
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • RBT1
  • NOS3 repressor of mutated NOS3
  • interacting with XRCC3 and RAD52
  • interaction with WRN or BLM helicases plays an important role in the mechanism for RPA stimulation of helicase-catalyzed DNA unwinding
  • first regulatory partner of BRIP1 (FANCJ) (BRIP1-RPA1 interaction is likely to be important for the role of the helicase to more efficiently unwind DNA repair intermediates to maintain genomic stability
  • direct interaction between RPA1 with both NBS1 and MRE11
  • PAXIP1 and RPA1, both involved in DNA replication and DNA repair, are HLTF-interacting proteins although cells depleted of HLTF did not show defects in cellular responses to DNA damage
  • interacts with the specific proteins among those that play roles in the regulation of the replication fork progression
  • upon replication blockage, WRN and RPA1 functionally interact and cooperate to help properly resolve replication forks and maintain genome stability
  • interacting with DMRT2 (potent inhibitor of the RPA1 displacing activity of HNRNPA1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS