| 1 | BLM, EXO5, RPA1
|
| EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
|
| Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA.
|
| Mol Cell. Jul 15;81(14):2989-3006.e9. doi: 10.1016/j.molcel.2021.05.027. Epub 2021 Jun 30. 2021
|
| 2 | ATRIP, ETAA1, RAD51, RPA1, TP53
|
| Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. 2020 PMID:
|
| Dueva R, Iliakis G.
|
| NAR Cancer. Sep 25;2(3):zcaa022. doi: 10.1093/narcan/zcaa022. 2020
|
| 3 | CHTF18, RPA1
|
| CTF18 interacts with replication protein A in response to replication stress.
|
| Kaneko Y, Daitoku H, Komeno C, Fukamizu A.
|
| Mol Med Rep 14(1):367-72. doi: 10.3892/mmr.2016.5262. Epub 2016 May 13. 2016
|
| 4 | ETAA1, RPA1
|
| RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.
|
| Lee YC, Zhou Q, Chen J, Yuan J
|
| Curr Biol. Dec 19;26(24):3257-3268. doi: 10.1016/j.cub.2016.10.030. Epub 2016 Nov 3. 2016
|
| 5 | FAN1, RPA1
|
| Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.
|
| Takahashi D, Sato K, Hirayama E, Takata M, Kurumizaka H.
|
| J Biochem. Sep;158(3):263-70. doi: 10.1093/jb/mvv043. Epub 2015 Apr 27 2015
|
| 6 | DNA2, RPA1
|
| Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
|
| Zhou C, Pourmal S, Pavletich NP.
|
| Elife 4. pii: e09832. doi: 10.7554/eLife.09832. [Epub ahead of print]
2015
|
| 7 | DNA2, RECQL, RPA1
|
| DNA2 drives processing and restart of reversed replication forks in human cells.
|
| Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A.
|
| J Cell Biol 208(5):545-62. doi: 10.1083/jcb.201406100.
2015
|
| 8 | BRCA2, RPA1, SHFM1
|
| Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.
|
| Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P.
|
| Mol Cell 59(2):176-87. doi: 10.1016/j.molcel.2015.05.032.
2015
|
| 9 | PALB2, RPA1
|
| Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery.
|
| Murphy AK, Fitzgerald M, Ro T, Kim JH, Rabinowitsch AI, Chowdhury D, Schildkraut CL, Borowiec JA.
|
| J Cell Biol 206(4):493-507. doi: 10.1083/jcb.201404111. Epub 2014 Aug 11.
2014
|
| 10 | BRIP1, RPA1, TERF2
|
| Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.
|
| Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M, Brosh RM Jr.
|
| J Biol Chem 289(29):19928-41. doi: 10.1074/jbc.M113.542456. Epub 2014 Jun 3.
2014
|
| 11 | RPA1, RPA2
|
| Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability.
|
| Safa L, Delagoutte E, Petruseva I, Alberti P, Lavrik O, Riou JF, Saintomé C.
|
| Biochimie 103:80-8. doi: 10.1016/j.biochi.2014.04.006. Epub 2014 Apr 18.
2014
|
| 12 | BCAS2, PRPF19, RPA1
|
| The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR).
|
| Wan L, Huang J.
|
| J Biol Chem 289(10):6619-26. doi: 10.1074/jbc.M113.543439. Epub 2014 Jan 17. 2014
|
| 13 | MEIOB, RPA1
|
| MEIOB targets single-strand DNA and is necessary for meiotic recombination.
|
| Souquet B, Abby E, Hervé R, Finsterbusch F, Tourpin S, Le Bouffant R, Duquenne C, Messiaen S, Martini E, Bernardino-Sgherri J, Toth A, Habert R, Livera G.
|
| PLoS Genet 9(9):e1003784. doi: 10.1371/journal.pgen.1003784. Epub 2013 Sep 19.
2013
|
| 14 | ATR, RPA1
|
| ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
|
| Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J.
|
| Cell 155(5):1088-103. doi: 10.1016/j.cell.2013.10.043. Erratum in: Cell. 2014 Jan 16;156(1-2):374.
2013
|
| 15 | ATR, RPA1
|
| DNA structure-specific priming of ATR activation by DNA-PKcs.
|
| Vidal-Eychenié S, Décaillet C, Basbous J, Constantinou A.
|
| J Cell Biol 202(3):421-9. doi: 10.1083/jcb.201304139. Epub 2013 Jul 29.
2013
|
| 16 | RPA1, TP53
|
| A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A.
|
| Glanzer JG, Carnes KA, Soto P, Liu S, Parkhurst LJ, Oakley GG.
|
| Nucleic Acids Res 41(3):2047-59. doi: 10.1093/nar/gks1291. Epub 2012 Dec 24.
2013
|
| 17 | AJUBA, RPA1
|
| LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response.
|
| Kalan S, Matveyenko A, Loayza D.
|
| Front Genet 4:95. doi: 10.3389/fgene.2013.00095.
2013
|
| 18 | RPA1, UNG
|
| Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
|
| Doseth B, Ekre C, Slupphaug G, Krokan HE, Kavli B.
|
| DNA Repair (Amst) 11(6):587-93. doi: 10.1016/j.dnarep.2012.03.003. Epub 2012 Apr 6.
2012
|
| 19 | HSF1, RPA1, SSRP1
|
| RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.
|
| Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.
|
| Mol Cell 48(2):182-94. doi: 10.1016/j.molcel.2012.07.026. Epub 2012 Aug 30. 2012
|
| 20 | RPA1, RPAIN
|
| Elevated level of human RPA interacting protein α (hRIPα) in cervical tumor cells is involved in cell proliferation through regulating RPA transport.
|
| Namkoong S, Lee EJ, Jang IS, Park J.
|
| FEBS Lett 586(20):3753-60. doi: 10.1016/j.febslet.2012.09.010. Epub 2012 Sep 23.
2012
|
| 21 | RPA1, WRN
|
| Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.
|
| Machwe A, Lozada E, Wold MS, Li GM, Orren DK.
|
| J Biol Chem 286(5):3497-508. Epub 2010 Nov 24.
2011
|
| 22 | DMRT2, HNRNPA1, POT1, RPA1
|
| TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.
|
| Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L.
|
| Nature 471(7339):532-6. Epub 2011 Mar 13.
2011
|
| 23 | RPA1
|
| Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome.
|
| Outwin E, Carpenter G, Bi W, Withers MA, Lupski JR, O'Driscoll M.
|
| PLoS Genet 7(8):e1002247. Epub 2011 Aug 25.
2011
|
| 24 | BID, RPA1
|
| BID binds to replication protein A and stimulates ATR function following replicative stress.
|
| Liu Y, Vaithiyalingam S, Shi Q, Chazin WJ, Zinkel SS.
|
| Mol Cell Biol 31(21):4298-309. doi: 10.1128/MCB.05737-11. Epub 2011 Aug 22.
2011
|
| 25 | ATRIP, BID, RPA1
|
| BID binds to replication protein A and stimulates ATR function following replicative stress.
|
| Liu Y, Vaithiyalingam S, Shi Q, Chazin WJ, Zinkel SS.
|
| Mol Cell Biol 31(21):4298-309. doi: 10.1128/MCB.05737-11. Epub 2011 Aug 22.
2011
|
| 26 | RPA1, XPA
|
| Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair.
|
| Krasikova YS, Rechkunova NI, Maltseva EA, Petruseva IO, Lavrik OI.
|
| Nucleic Acids Res 38(22):8083-94. Epub 2010 Aug 6.
2010
|
| 27 | RPA1, RPA2, RPA3
|
| Identification of proteins that may directly interact with human RPA.
|
| Nakaya R, Takaya J, Onuki T, Moritani M, Nozaki N, Ishimi Y.
|
| J Biochem 148(5):539-47. Epub 2010 Aug 2.
2010
|
| 28 | RPA1, RPA2, RPA3
|
| Functions of alternative replication protein A in initiation and elongation.
|
| Mason AC, Roy R, Simmons DT, Wold MS.
|
| Biochemistry 49(28):5919-28.
2010
|
| 29 | BRIP1, RPA1
|
| FANCJ Helicase Uniquely Senses Oxidative Base Damage in Either Strand of Duplex DNA and Is Stimulated by Replication Protein A to Unwind the Damaged DNA Substrate in a Strand-specific Manner.
|
| Suhasini AN, Sommers JA, Mason AC, Voloshin ON, Camerini-Otero RD, Wold MS, Brosh RM Jr.
|
| J Biol Chem 284(27):18458-70. Epub 2009 May 5. 2009
|
| 30 | RPA1, RPA2
|
| Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.
|
| Oakley GG, Tillison K, Opiyo SA, Glanzer JG, Horn JM, Patrick SM.
|
| Biochemistry 48(31):7473-81.PMID: 19586055 2009
|
| 31 | HLTF, PAXIP1, RPA1
|
| Biochemical characterisation of the SWI/SNF family member HLTF.
|
| MacKay C, Toth R, Rouse J.
|
| Biochem Biophys Res Commun 390(2):187-91. Epub 2009 Aug 31.
2009
|
| 32 | RPA1, RPA2, RPA3
|
| Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA.
|
| Salas TR, Petruseva I, Lavrik O, Saintomé C.
|
| Nucleic Acids Res 37(1):38-46. Epub 2008 Nov 14.
2009
|
| 33 | RPA1, RPAIN
|
| Species-specific variation of RPA-interacting protein (RIP) splice isoforms.
|
| Kim K, Lee EJ, Lee SH, Seo T, Jang IS, Park J, Lee JH.
|
| BMB Rep 42(1):22-7.
2009
|
| 34 | RFC2, RPA1
|
| DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex.
|
| Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T.
|
| J Biol Chem 283(14):9071-9. Epub 2008 Feb 1.PMID: 18245774 2008
|
| 35 | ATR, BPES, MDS, RCF2, RPA1, SCKL1, WBS
|
| Cellular and Clinical Impact of Haploinsufficiency for Genes Involved in ATR Signaling.
|
| O'Driscoll M, Dobyns WB, van Hagen JM, Jeggo PA.
|
| Am J Hum Genet 81(1):77-86. Epub 2007 May 17. 2007
|
| 36 | BRIP1, RPA1
|
| FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
|
| Gupta R, Sharma S, Sommers JA, Kenny MK, Cantor SB, Brosh RM Jr.
|
| Blood 110(7):2390-8. Epub 2007 Jun 27.PMID: 17596542 2007
|
| 37 | WRN, RPA1, BLM
|
| Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
|
| Doherty KM, Sommers JA, Gray MD, Lee JW, von Kobbe C, Thoma NH, Kureekattil RP, Kenny MK, Brosh RM Jr.
|
| J Biol Chem 280(33):29494-505. Epub 2005 Jun 17. 2005
|
| 38 | RPA1
|
| RPA regulates telomerase action by providing Est1p access to chromosome ends.
|
| Schramke V, Luciano P, Brevet V, Guillot S, Corda Y, Longhese MP, Gilson E, Geli V.
|
| Nat Genet 36(1):46-54. Epub 2003 Dec 21. 2004
|
| 39 | XRCC3, RPA1
|
| XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells.
|
| Yoshihara T, Ishida M, Kinomura A, Katsura M, Tsuruga T, Tashiro S, Asahara T, Miyagawa K.
|
| EMBO J 23(3):670-80. Epub 2004 Jan 29. 2004
|
| 40 | RPA1, RPA2, RPA3
|
| Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA.
|
| Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A.
|
| EMBO J 21(7):1855-63.
2002
|
| 41 | RPA1, RPA2, XPA
|
| Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair.
|
| Missura M, Buterin T, Hindges R, Hubscher U, Kasparkova J, Brabec V, Naegeli H.
|
| EMBO J 20(13):3554-64. 2001
|
| 42 | NOS3, RPA1
|
| Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina.
|
| Miyamoto Y, Saito Y, Nakayama M, Shimasaki Y, Yoshimura T, Yoshimura M, Harada M, Kajiyama N, Kishimoto I, Kuwahara K, Hino J, Ogawa E, Hamanaka I, Kamitani S, Takahashi N, Kawakami R, Kangawa K, Yasue H, Nakao K.
|
| Hum Mol Genet 9(18):2629-37. 2000
|
| 43 | BLM, RPA1, RPA2, RPA3
|
| Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes.
|
| Walpita D, et al.
|
| Proc Natl Acad Sci U S A 96(10):5622-7. 1999
|
| 44 | RPA1
|
| Replication protein A interactions with DNA. 1. Functions of the DNA-binding and zinc-finger domains of the 70-kDa subunit.
|
| Walther AP, et al.
|
| Biochemistry 38(13):3963-73. 1999
|
| 45 | RPA1
|
| Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions.
|
| Lao Y, et al.
|
| Biochemistry 38(13):3974-84. 1999
|
| 46 | RAD51, RAD52, RPA1
|
| Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52.
|
| Baumann P, West SC.
|
| J Mol Biol 291(2):363-74. 1999
|
| 47 | RAD51, RPA1
|
| Interaction of human Rad51 recombination protein with single-stranded DNA binding protein, RPA.
|
| Golub EI, Gupta RC, Haaf T, Wold MS, Radding CM.
|
| Nucleic Acids Res 26(23):5388-93. 1998
|
| 48 | ATM, ATR, BLM, MLH1, RAD51, RPA1, RPA2, RPA3
|
| Changes in protein composition of meiotic nodules during mammalian meiosis.
|
| Plug AW, et al.
|
| J Cell Sci 111 ( Pt 4):413-23. 1998
|
| 49 | RPA1, RPA2, RPA3
|
| Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system.
|
| Kazantsev A, et al.
|
| Proc Natl Acad Sci U S A 93 : 5014-5018. 1996
|
| 50 | XPA, RPA1
|
| Human xeroderma pigmentosum group A protein interacts with human replication protein A and inhibits DNA replication.
|
| Lee SH, et al.
|
| J Biol Chem 270 : 21800-21805. 1995
|
| 51 | RPA1, RPA2, RPA3
|
| High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3).
|
| Umbricht CB, et al.
|
| Genomics 20 : 249-257. 1994
|
| 52 | RPA1, RPA2, RPA3
|
| Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A.
|
| Umbricht CB, et al.
|
| J Biol Chem 268 : 6131-6138. 1993
|
| 53 | RPA1, RPA2, RPA3
|
| Mapping of the 70 kDa, 34 kDa, and a 11 kDa subunit of the human multimeric single-stranded DNA binding protein (hSSB/RPA) to chromosome bands 17p13, 1p35-p36.1, and 7p21-p22.
|
| Ozawa K, et al.
|
| Cell Struct Funct 18 : 221-230. 1993
|