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FLASH GENE
Symbol SLC2A4 contributors: mct - updated : 08-04-2010
HGNC name solute carrier family 2 (facilitated glucose transporter), member 4
HGNC id 11009
Location 17p13.1      Physical location : 7.185.053 - 7.191.366
Synonym name
  • glucose transporter 4, insuline-responsive
  • insulin-responsive glucose transporter type 4
  • Synonym symbol(s) GLUT4
    DNA
    TYPE functioning gene
    STRUCTURE 6.31 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer   transcription factor   HRE
    text structure
  • promoter regulated through the cooperative function of two distinct regulatory elements SLC2A4RG and MEF2A
  • an Sp1 binding site adjacent to the functional sterol-response element
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC388328 17 LOC388328 MGC49942 17p13.2 hypothetical protein MGC49942 BCL6B 17p13.1 B-cell CLL/lymphoma 6, member B (zinc finger protein) LOC201232 SLC16A11 17p13.2 solute carrier family 16 (monocarboxylic acid transporters), member 11 CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 ASGR2 17p13.1 asialoglycoprotein receptor 2 ASGR1 17p12 asialoglycoprotein receptor 1 DLG4 17p13.1 discs, large (Drosophila) homolog 4 ACADVL 17p13.1 acyl-Coenzyme A dehydrogenase, very long chain DVL2 17p13.2 dishevelled, dsh homolog 2 (Drosophila) MGC2941 17p13.2 hypothetical protein MGC2941 GABARAP 17p13.1 GABA(A) receptor-associated protein DULLARD 17p13 dullard homolog (Xenopus laevis) DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein EIF5A 17p13-p12 eukaryotic translation initiation factor 5A GPS2 17p13 G protein pathway suppressor 2 LOC390760 17 similar to RIKEN cDNA 2810408A11 CENTB1 17p13.2 centaurin, beta 1 KCTD11 17p13.2 potassium channel tetramerisation domain containing 11 LOC339168 17p13.2 hypothetical protein LOC339168 TNK1 17p13.1 tyrosine kinase, non-receptor, 1 PLSCR3 17p13.2 phospholipid scramblase 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3159 - 509 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Connectivebone   
    Muscularstriatumskeletal  
    skeleton    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments (12TM)
  • intracellular N and C termini
  • a large extracellular loop
  • a glycosylation site between TM1 and 2
  • a small and a large intracellular loops, respectively between TM2 and 3 and TM8 and 9, both with the conserved RXGRR motif
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • sugar transporter family
  • glucose transporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • stimulation of glucose uptake by insulin requires translocation of SLC24A to intracellular storage sites to cell surface
  • AXIN1, TNKS2 and KIF3A are co-localized with SLC2A4 on the trans-Golgi network
  • basic FUNCTION
  • facilitated glucose transporter
  • mediating insulin-stimulated glucose uptake in adipocytes and muscle by rapidly moving from intracellular storage sites to the plasma membrane
  • specific role in glucose homeostasis in conjunction with LNPEP
  • mediating the postprandial blood glucose clearance
  • role for LNPEP and SLC2A4 in activity-dependent glucose uptake in hippocampal neurones
  • dynamically retained through idle cycling among selective intracellular compartments, from whence it undergoes slow recycling to the plasma membrane (PM)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • C-ter is required for protein targeting to the perinuclear donor membranes but not to the insulin-responsive vesicles
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC2A4RG and MEF2A to activate SLC2A4 transcription
  • interacting with SGK1 (stimulates glucose transport by enhancing the abundance of SLC2A4 in the cell membrane at least in part via direct SLC2A4 phosphorylation)
  • interacting with TBC1D4
  • interacting with VAMP4, VAMP8, VAMP2 (requirement for VAMP4 for the initial biosynthetic entry of SLC2A4 from the Golgi apparatus into the insulin-responsive vesicle compartment, VAMP8, for plasma membrane endocytosis and VAMP2 for sorting to the specialized insulin-responsive compartment after plasma membrane endocytosis)
  • AXIN1 interacts with the ADP-ribosylase tankyrase 2 (TNKS2) and the kinesin motor protein KIF3A, forming a ternary complex crucial for SLC2A4 translocation in response to insulin
  • cell & other
    REGULATION
    Other translocated to plasma membrane for insulin stimulated glucose uptake,requiring activation of phosphatidylinositol-3-OH kinase (PI(3)K) and activation of TC10 (essential)
    may be regulated by PLAGL1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in adipose tissue but preserved in muscle in insuline-resitant states such as obesity and type 2 diabetes
    Susceptibility non insulin dependent diabetes mellitus (type 2)
    Variant & Polymorphism polymorphic variant
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    G4A -/- mice