Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF31 contributors: mct - updated : 28-06-2016
HGNC name ring finger protein 31
HGNC id 16031
Location 14q11.2      Physical location : 24.616.658 - 24.629.870
Synonym name
  • HOIL-1L-interacting protein
    • Synonym symbol(s) ZIBRA, FLJ10111, FLJ23501, HOIP
    DNA
    TYPE functioning gene
    STRUCTURE 13.21 kb     21 Exon(s)
    regulatory sequence Binding site   hormone
    text structure a TFIID/TBP/Sp1 consensus site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3571 - 1072 - 2004 15093743
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
    cell lineage
    cell lines oligodendroglioma, bronchioalveolar, papillary serous, borderline ovarian, breast carcinomas
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text head, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three RING finger motifs
  • an ubiquitin-associated (UBA) domain
  • an in-between-ring-finger (IBR) domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may have an ubiquitin ligase activity
  • functions to stabilize NR0B1, which might be linked to NR0B1 monoubiquitination
  • is a ubiquitin ligase capable of mediating NF-kappaB activation through the ubiquitin-dependent activation of IKBKG
  • important role for the ubiquitin ligase activity of RNF31 in proximal CD40 signaling
  • appears to be required for NR0B1 to repress transcription, providing means to regulate NR0B1 in ligand-independent ways
  • key component of the CD40 signaling pathway
  • combines a general RING-IBR-RING (RBR) ubiquitin ligase mechanism with unique, 'Linear ubiquitin chain Determining Domain' (LDD)-dependent specificity for producing linear ubiquitin chains
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • the UBL domains of RBCK1 and SHARPIN are required for the binding to RNF31 to assemble LUBAC
  • upon binding to the LUBAC subunit RNF31, SHARPIN stimulates the formation of linear ubiquitin chains
  • SHARPIN activates NFKB1 signaling by forming a linear ubiquitin chain assembly complex with RNF31 (HOIP) and RBCK1 (HOIL1)
  • TRAF2 mediates recruitment of RNF31 to the cytoplasmic domain of CD40, suggesting that RNF31 has a role in the CD40 signaling pathway
  • RNF31 binding to OTULIN is required for the recruitment of OTULIN to the TNF receptor complex and to counteract RNF31-dependent activation of the NFKB1 pathway
  • co operates with the E3 ubiquitin ligase RNF31 to modify specific NFKB1 signaling proteins with linear M1-linked polyubiquitin chains
    • cell & other
    REGULATION
    Other translationally regulated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS