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FLASH GENE
Symbol RNF31 contributors: mct - updated : 28-06-2014
HGNC name ring finger protein 31
HGNC id 16031
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3571 - 1072 - 2004 15093743
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta   
cell lineage
cell lines oligodendroglioma, bronchioalveolar, papillary serous, borderline ovarian, breast carcinomas
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text head, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RING finger motifs
  • an ubiquitin-associated (UBA) domain
  • an in-between-ring-finger (IBR) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may have an ubiquitin ligase activity
  • functions to stabilize NR0B1, which might be linked to NR0B1 monoubiquitination
  • is a ubiquitin ligase capable of mediating NF-kappaB activation through the ubiquitin-dependent activation of IKBKG
  • important role for the ubiquitin ligase activity of RNF31 in proximal CD40 signaling
  • appears to be required for NR0B1 to repress transcription, providing means to regulate NR0B1 in ligand-independent ways
  • key component of the CD40 signaling pathway
  • combines a general RING-IBR-RING (RBR) ubiquitin ligase mechanism with unique, 'Linear ubiquitin chain Determining Domain' (LDD)-dependent specificity for producing linear ubiquitin chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • the UBL domains of RBCK1 and SHARPIN are required for the binding to RNF31 to assemble LUBAC
  • upon binding to the LUBAC subunit RNF31, SHARPIN stimulates the formation of linear ubiquitin chains
  • SHARPIN activates NFKB1 signaling by forming a linear ubiquitin chain assembly complex with RNF31 (HOIP) and RBCK1 (HOIL1)
  • TRAF2 mediates recruitment of RNF31 to the cytoplasmic domain of CD40, suggesting that RNF31 has a role in the CD40 signaling pathway
  • co operates with the E3 ubiquitin ligase RNF31 to modify specific NFKB1 signaling proteins with linear M1-linked polyubiquitin chains
  • cell & other
    REGULATION
    Other translationally regulated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS