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FLASH GENE
Symbol RNF31 contributors: mct - updated : 28-06-2014
HGNC name ring finger protein 31
HGNC id 16031
DNA
TYPE functioning gene
STRUCTURE 13.21 kb     21 Exon(s)
regulatory sequence Binding site   hormone
text structure a TFIID/TBP/Sp1 consensus site
MAPPING cloned Y linked N status provisional
Physical map
DHRS4 14q11.2-14q21.3 dehydrogenase/reductase (SDR family) member 4 DHRS4L2 14 dehydrogenase/reductase (SDR family) member 4 like 2 LOC387975 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase LOC90668 14q11.2 hypothetical protein BC008134 CPNE6 14q11.2 copine VI (neuronal) NRL 14q11.1-q11.2 neural retina leucine zipper PCK2 14q11.2-q12 phosphoenolpyruvate carboxykinase 2 (mitochondrial) WDR23 14q11.2 WD repeat domain 23 LOC161247 14q11.2 similar to 1110028A07Rik protein PSME1 14q11.2 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) C14orf122 14q11.2 chromosome 14 open reading frame 122 PSME2 14q11.2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) RNF31 14q11.2 ring finger protein 31 ISGF3G 14q11.2 interferon-stimulated transcription factor 3, gamma 48kDa REC8L1 14q11.2-q12 REC8-like 1 (yeast) IPO4 14q11.2 importin 4 TM9SF1 14q11.2 transmembrane 9 superfamily member 1 C14orf20 14q11.2 chromosome 14 open reading frame 20 C14orf123 14q11.2 chromosome 14 open reading frame 123 MGC5987 14q11.2 hypothetical protein MGC5987 NEDD8 14q11.2 neural precursor cell expressed, developmentally down-regulated 8 GMPR2 14q11.2 guanosine monophosphate reductase 2 TINF2 14q11.2 TERF1 (TRF1)-interacting nuclear factor 2 TGM1 14q11.2 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) RABGGTA 14q11.2 Rab geranylgeranyltransferase, alpha subunit DHRS1 14q11.2 dehydrogenase/reductase (SDR family) member 1 C14orf21 14q11.2 chromosome 14 open reading frame 21 CIDEB 14q11.2 cell death-inducing DFFA-like effector b LTB4R2 14q11.2-q12 leukotriene B4 receptor 2 LTB4R 14q11.2-q12 leukotriene B4 receptor ADCY4 14q11.2 adenylate cyclase 4 RIPK3 14q11.2 receptor-interacting serine-threonine kinase 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3571 - 1072 - 2004 15093743
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta   
cell lineage
cell lines oligodendroglioma, bronchioalveolar, papillary serous, borderline ovarian, breast carcinomas
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text head, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RING finger motifs
  • an ubiquitin-associated (UBA) domain
  • an in-between-ring-finger (IBR) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may have an ubiquitin ligase activity
  • functions to stabilize NR0B1, which might be linked to NR0B1 monoubiquitination
  • is a ubiquitin ligase capable of mediating NF-kappaB activation through the ubiquitin-dependent activation of IKBKG
  • important role for the ubiquitin ligase activity of RNF31 in proximal CD40 signaling
  • appears to be required for NR0B1 to repress transcription, providing means to regulate NR0B1 in ligand-independent ways
  • key component of the CD40 signaling pathway
  • combines a general RING-IBR-RING (RBR) ubiquitin ligase mechanism with unique, 'Linear ubiquitin chain Determining Domain' (LDD)-dependent specificity for producing linear ubiquitin chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • the UBL domains of RBCK1 and SHARPIN are required for the binding to RNF31 to assemble LUBAC
  • upon binding to the LUBAC subunit RNF31, SHARPIN stimulates the formation of linear ubiquitin chains
  • SHARPIN activates NFKB1 signaling by forming a linear ubiquitin chain assembly complex with RNF31 (HOIP) and RBCK1 (HOIL1)
  • TRAF2 mediates recruitment of RNF31 to the cytoplasmic domain of CD40, suggesting that RNF31 has a role in the CD40 signaling pathway
  • co operates with the E3 ubiquitin ligase RNF31 to modify specific NFKB1 signaling proteins with linear M1-linked polyubiquitin chains
  • cell & other
    REGULATION
    Other translationally regulated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS