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FLASH GENE
Symbol RNF31 contributors: mct - updated : 28-06-2014
HGNC name ring finger protein 31
HGNC id 16031
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RING finger motifs
  • an ubiquitin-associated (UBA) domain
  • an in-between-ring-finger (IBR) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may have an ubiquitin ligase activity
  • functions to stabilize NR0B1, which might be linked to NR0B1 monoubiquitination
  • is a ubiquitin ligase capable of mediating NF-kappaB activation through the ubiquitin-dependent activation of IKBKG
  • important role for the ubiquitin ligase activity of RNF31 in proximal CD40 signaling
  • appears to be required for NR0B1 to repress transcription, providing means to regulate NR0B1 in ligand-independent ways
  • key component of the CD40 signaling pathway
  • combines a general RING-IBR-RING (RBR) ubiquitin ligase mechanism with unique, 'Linear ubiquitin chain Determining Domain' (LDD)-dependent specificity for producing linear ubiquitin chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • the UBL domains of RBCK1 and SHARPIN are required for the binding to RNF31 to assemble LUBAC
  • upon binding to the LUBAC subunit RNF31, SHARPIN stimulates the formation of linear ubiquitin chains
  • SHARPIN activates NFKB1 signaling by forming a linear ubiquitin chain assembly complex with RNF31 (HOIP) and RBCK1 (HOIL1)
  • TRAF2 mediates recruitment of RNF31 to the cytoplasmic domain of CD40, suggesting that RNF31 has a role in the CD40 signaling pathway
  • co operates with the E3 ubiquitin ligase RNF31 to modify specific NFKB1 signaling proteins with linear M1-linked polyubiquitin chains
  • cell & other
    REGULATION
    Other translationally regulated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS