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FLASH GENE
Symbol RNF11 contributors: mct/npt - updated : 13-06-2015
HGNC name ring finger protein 11
HGNC id 10056
Location 1p32.3      Physical location : 51.701.944 - 51.739.117
Synonym name Sid 1669
Synonym symbol(s) CGI-123, Sid1669p, MGC51169, SID1669
DNA
TYPE functioning gene
STRUCTURE 37.17 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ELAVL4 1p34 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) LOC343184 1p33 similar to ribosomal protein S2 LOC391038 1 similar to Protein C14orf111 (CGI-35) DMRTA2 1p33 DMRT-like family A2 FAF1 1p33 Fas (TNFRSF6) associated factor 1 MRPS6P2 1p33 mitochondrial ribosomal protein S6 pseudogene 2 LOC51336 1p32.3 mesenchymal stem cell protein DSCD28 CDKN2C 1p32 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) LOC284546 1p32.3 similar to RIKEN cDNA 4930522H14 LOC391039 1 similar to Cofilin, non-muscle isoform (18 kDa phosphoprotein) (P18) RNF11 1p32-p31 ring finger protein 11 LOC388631 1 similar to ribosomal protein S2; 40S ribosomal protein S2 C1orf34 1p33 chromosome 1 open reading frame 34 EPS15 1p32.2-p31 epidermal growth factor receptor pathway substrate 15 OSBPL9 1p34.2-p32.2 oxysterol binding protein-like 9 NRD1 1p32.2 nardilysin (N-arginine dibasic convertase) RAB3B 1p32-p31 RAB3B, member RAS oncogene family TLP19 1p32.3 endoplasmic reticulum thioredoxin superfamily member, 18 kDa LOC112970 1p32.3 hypothetical protein BC012173 LOC391040 1 similar to RIKEN cDNA 5730434I03 gene MADHIP 1p32.3 MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor KIAA1836 1p32.3 KIAA1836 protein ORC1L 1p32 origin recognition complex, subunit 1-like (yeast) FLJ14936 1p33-p32.1 hypothetical protein FLJ14936 KIAA0191 1p31-32 hypothetical protein FLJ14936 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3082 - 154 - 1999 10673045
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrainsubstantia nigra highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RING H2 domain (C3HC4 finger motif), common to E3 ubiquitin ligases such as parkin at the C terminal region (Anderson 2007)
  • a PY motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • RING finger protein family
  • CATEGORY DNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative regulator of ERBB2 and EGFR (Chen 2008)
  • negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways (Shembade 2009)
  • required for TNFAIP3 to interact with and inactivate RIPK1 to inhibit TNF-mediated NF-kappaB activation (Shembade 2009)
  • together with TAX1BP1 and ITCH, is an essential component of an TNFAIP3 ubiquitin-editing protein complex that ensures transient activation of inflammatory signalling pathways (Shembade 2009)
  • correlation between high RNF11 expression, as in tumor cells, and a swelling of the endosomal compartment suggesting a possible role of the dysregulation of the endosome compartment in tumorigenesis
  • in the nervous system, RNF11 negatively regulates canonical NFKB1 signaling
  • RNF11 and ZFYVE9 participate structurally and functionally in the ESCRT-dependent lysosomal degradation of receptors
  • neuron-specific role of RNF11 in the brain has important implications for targeted therapeutics aimed at preventing neurodegeneration
  • negative regulator of NFKB1 signaling pathway, colocalizes with SNCA and is sequestered in Lewy bodies in Parkinson disease (PD)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WWP1 forms a protein complex with RNF11 (Chen 2008)
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacted with the NF-kappaB inhibitor TNFAIP3 and its regulatory protein TAX1BP1 in a stimulus-dependent manner (Shembade 2009)
  • interaction with WWP1 through the first and third WW domains of WWP1 and the PY motif of RNF11
  • RNF11 and TNFAIP3 interact in a microglial cell line, suggesting the presence of TNFAIP3 ubiquitin-editing protein complex in microglial cells
  • is a ZFYVE9-interacting protein residing on early and late endosomes, as well as the fast recycling compartment
  • ZFYVE9 interact with RNF11 (RING finger protein 11) and members of the ESCRT-0 (endosomal sorting complex required for transport) complex functionally participating in the degradation of EGFR
  • RNF11 inhibits MC3R, MC4R signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    RING domain protein RNF11 is overexpressed in breast cancers (Shembade 2009)
    constitutional     --low  
    neuronal RNF11 expression was down-regulated in Parkinson disease and usually associated with increased expression of phospho RELA
    tumoral     --over  
    in numerous human prostate, colon and invasive breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene strong candidate gene at the PARK10 locus (potential significance in the development of the common form of Parkinson disease) (Anderson 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS