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Symbol RNF11 contributors: mct/npt - updated : 13-06-2015
HGNC name ring finger protein 11
HGNC id 10056
Location 1p32.3      Physical location : 51.701.944 - 51.739.117
Synonym name Sid 1669
Synonym symbol(s) CGI-123, Sid1669p, MGC51169, SID1669
TYPE functioning gene
STRUCTURE 37.17 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ELAVL4 1p34 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) LOC343184 1p33 similar to ribosomal protein S2 LOC391038 1 similar to Protein C14orf111 (CGI-35) DMRTA2 1p33 DMRT-like family A2 FAF1 1p33 Fas (TNFRSF6) associated factor 1 MRPS6P2 1p33 mitochondrial ribosomal protein S6 pseudogene 2 LOC51336 1p32.3 mesenchymal stem cell protein DSCD28 CDKN2C 1p32 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) LOC284546 1p32.3 similar to RIKEN cDNA 4930522H14 LOC391039 1 similar to Cofilin, non-muscle isoform (18 kDa phosphoprotein) (P18) RNF11 1p32-p31 ring finger protein 11 LOC388631 1 similar to ribosomal protein S2; 40S ribosomal protein S2 C1orf34 1p33 chromosome 1 open reading frame 34 EPS15 1p32.2-p31 epidermal growth factor receptor pathway substrate 15 OSBPL9 1p34.2-p32.2 oxysterol binding protein-like 9 NRD1 1p32.2 nardilysin (N-arginine dibasic convertase) RAB3B 1p32-p31 RAB3B, member RAS oncogene family TLP19 1p32.3 endoplasmic reticulum thioredoxin superfamily member, 18 kDa LOC112970 1p32.3 hypothetical protein BC012173 LOC391040 1 similar to RIKEN cDNA 5730434I03 gene MADHIP 1p32.3 MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor KIAA1836 1p32.3 KIAA1836 protein ORC1L 1p32 origin recognition complex, subunit 1-like (yeast) FLJ14936 1p33-p32.1 hypothetical protein FLJ14936 KIAA0191 1p31-32 hypothetical protein FLJ14936 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1)
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3082 - 154 - 1999 10673045
Type ubiquitous
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrainsubstantia nigra highly
SystemCellPubmedSpeciesStageRna symbol
cell lineage
cell lines
  • RING H2 domain (C3HC4 finger motif), common to E3 ubiquitin ligases such as parkin at the C terminal region (Anderson 2007)
  • a PY motif
  • conjugated MetalloP
  • RING finger protein family
  • CATEGORY DNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • negative regulator of ERBB2 and EGFR (Chen 2008)
  • negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways (Shembade 2009)
  • required for TNFAIP3 to interact with and inactivate RIPK1 to inhibit TNF-mediated NF-kappaB activation (Shembade 2009)
  • together with TAX1BP1 and ITCH, is an essential component of an TNFAIP3 ubiquitin-editing protein complex that ensures transient activation of inflammatory signalling pathways (Shembade 2009)
  • correlation between high RNF11 expression, as in tumor cells, and a swelling of the endosomal compartment suggesting a possible role of the dysregulation of the endosome compartment in tumorigenesis
  • in the nervous system, RNF11 negatively regulates canonical NFKB1 signaling
  • RNF11 and ZFYVE9 participate structurally and functionally in the ESCRT-dependent lysosomal degradation of receptors
  • neuron-specific role of RNF11 in the brain has important implications for targeted therapeutics aimed at preventing neurodegeneration
  • negative regulator of NFKB1 signaling pathway, colocalizes with SNCA and is sequestered in Lewy bodies in Parkinson disease (PD)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    a component
  • WWP1 forms a protein complex with RNF11 (Chen 2008)
    DNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • interacted with the NF-kappaB inhibitor TNFAIP3 and its regulatory protein TAX1BP1 in a stimulus-dependent manner (Shembade 2009)
  • interaction with WWP1 through the first and third WW domains of WWP1 and the PY motif of RNF11
  • RNF11 and TNFAIP3 interact in a microglial cell line, suggesting the presence of TNFAIP3 ubiquitin-editing protein complex in microglial cells
  • is a ZFYVE9-interacting protein residing on early and late endosomes, as well as the fast recycling compartment
  • ZFYVE9 interact with RNF11 (RING finger protein 11) and members of the ESCRT-0 (endosomal sorting complex required for transport) complex functionally participating in the degradation of EGFR
  • RNF11 inhibits MC3R, MC4R signaling
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    RING domain protein RNF11 is overexpressed in breast cancers (Shembade 2009)
    constitutional     --low  
    neuronal RNF11 expression was down-regulated in Parkinson disease and usually associated with increased expression of phospho RELA
    tumoral     --over  
    in numerous human prostate, colon and invasive breast cancers
    Variant & Polymorphism
    Candidate gene strong candidate gene at the PARK10 locus (potential significance in the development of the common form of Parkinson disease) (Anderson 2007)
    Therapy target