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FLASH GENE

Symbol

RNF11

contributors: mct/npt - updated : 13-06-2015

HGNC name	ring finger protein 11
HGNC id	10056

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain midbrain substantia nigra   highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RING H2 domain (C3HC4 finger motif), common to E3 ubiquitin ligases such as parkin at the C terminal region (Anderson 2007)
	a PY motif

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

RING finger protein family

CATEGORY

DNA associated , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	negative regulator of ERBB2 and EGFR (Chen 2008)
	negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways (Shembade 2009)
	required for TNFAIP3 to interact with and inactivate RIPK1 to inhibit TNF-mediated NF-kappaB activation (Shembade 2009)
	together with TAX1BP1 and ITCH, is an essential component of an TNFAIP3 ubiquitin-editing protein complex that ensures transient activation of inflammatory signalling pathways (Shembade 2009)
	correlation between high RNF11 expression, as in tumor cells, and a swelling of the endosomal compartment suggesting a possible role of the dysregulation of the endosome compartment in tumorigenesis
	in the nervous system, RNF11 negatively regulates canonical NFKB1 signaling
	RNF11 and ZFYVE9 participate structurally and functionally in the ESCRT-dependent lysosomal degradation of receptors
	neuron-specific role of RNF11 in the brain has important implications for targeted therapeutics aimed at preventing neurodegeneration
	negative regulator of NFKB1 signaling pathway, colocalizes with SNCA and is sequestered in Lewy bodies in Parkinson disease (PD)

CELLULAR PROCESS	nucleotide, transcription, regulation
	protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

WWP1 forms a protein complex with RNF11 (Chen 2008)

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	interacted with the NF-kappaB inhibitor TNFAIP3 and its regulatory protein TAX1BP1 in a stimulus-dependent manner (Shembade 2009)
	interaction with WWP1 through the first and third WW domains of WWP1 and the PY motif of RNF11
	RNF11 and TNFAIP3 interact in a microglial cell line, suggesting the presence of TNFAIP3 ubiquitin-editing protein complex in microglial cells
	is a ZFYVE9-interacting protein residing on early and late endosomes, as well as the fast recycling compartment
	ZFYVE9 interact with RNF11 (RING finger protein 11) and members of the ESCRT-0 (endosomal sorting complex required for transport) complex functionally participating in the degradation of EGFR
	RNF11 inhibits MC3R, MC4R signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   RING domain protein RNF11 is overexpressed in breast cancers (Shembade 2009) constitutional     --low   neuronal RNF11 expression was down-regulated in Parkinson disease and usually associated with increased expression of phospho RELA tumoral     --over   in numerous human prostate, colon and invasive breast cancers

Susceptibility

Variant & Polymorphism

Candidate gene	strong candidate gene at the PARK10 locus (potential significance in the development of the common form of Parkinson disease) (Anderson 2007)
Marker
Therapy target

ANIMAL & CELL MODELS