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FLASH GENE

Symbol

RNF11

contributors: mct/npt - updated : 13-06-2015

HGNC name	ring finger protein 11
HGNC id	10056

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   RING domain protein RNF11 is overexpressed in breast cancers (Shembade 2009) constitutional     --low   neuronal RNF11 expression was down-regulated in Parkinson disease and usually associated with increased expression of phospho RELA tumoral     --over   in numerous human prostate, colon and invasive breast cancers

Susceptibility

Variant & Polymorphism

Candidate gene	strong candidate gene at the PARK10 locus (potential significance in the development of the common form of Parkinson disease) (Anderson 2007)
Marker
Therapy target

ANIMAL & CELL MODELS