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FLASH GENE
Symbol RNF11 contributors: mct/npt - updated : 13-06-2015
HGNC name ring finger protein 11
HGNC id 10056
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RING H2 domain (C3HC4 finger motif), common to E3 ubiquitin ligases such as parkin at the C terminal region (Anderson 2007)
  • a PY motif
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • RING finger protein family
    • CATEGORY DNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative regulator of ERBB2 and EGFR (Chen 2008)
  • negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways (Shembade 2009)
  • required for TNFAIP3 to interact with and inactivate RIPK1 to inhibit TNF-mediated NF-kappaB activation (Shembade 2009)
  • together with TAX1BP1 and ITCH, is an essential component of an TNFAIP3 ubiquitin-editing protein complex that ensures transient activation of inflammatory signalling pathways (Shembade 2009)
  • correlation between high RNF11 expression, as in tumor cells, and a swelling of the endosomal compartment suggesting a possible role of the dysregulation of the endosome compartment in tumorigenesis
  • in the nervous system, RNF11 negatively regulates canonical NFKB1 signaling
  • RNF11 and ZFYVE9 participate structurally and functionally in the ESCRT-dependent lysosomal degradation of receptors
  • neuron-specific role of RNF11 in the brain has important implications for targeted therapeutics aimed at preventing neurodegeneration
  • negative regulator of NFKB1 signaling pathway, colocalizes with SNCA and is sequestered in Lewy bodies in Parkinson disease (PD)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WWP1 forms a protein complex with RNF11 (Chen 2008)
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacted with the NF-kappaB inhibitor TNFAIP3 and its regulatory protein TAX1BP1 in a stimulus-dependent manner (Shembade 2009)
  • interaction with WWP1 through the first and third WW domains of WWP1 and the PY motif of RNF11
  • RNF11 and TNFAIP3 interact in a microglial cell line, suggesting the presence of TNFAIP3 ubiquitin-editing protein complex in microglial cells
  • is a ZFYVE9-interacting protein residing on early and late endosomes, as well as the fast recycling compartment
  • ZFYVE9 interact with RNF11 (RING finger protein 11) and members of the ESCRT-0 (endosomal sorting complex required for transport) complex functionally participating in the degradation of EGFR
  • RNF11 inhibits MC3R, MC4R signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    RING domain protein RNF11 is overexpressed in breast cancers (Shembade 2009)
    constitutional     --low  
    neuronal RNF11 expression was down-regulated in Parkinson disease and usually associated with increased expression of phospho RELA
    tumoral     --over  
    in numerous human prostate, colon and invasive breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene strong candidate gene at the PARK10 locus (potential significance in the development of the common form of Parkinson disease) (Anderson 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS