Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLXNA3 contributors: mct - updated : 30-08-2017
HGNC name plexin A3
HGNC id 9101
Location Xq28      Physical location : 153.686.622 - 153.701.984
Synonym name
  • single pass transmembrane protein SEX/Plexin 4
  • Sex chromosome X transmembrane protein of HGF receptor family 3
    • Synonym symbol(s) PLXN3, SEX, XAP6, PLXNA6-3, PLXN4, XAP-6, HSSEXGENE
    DNA
    TYPE functioning gene
    STRUCTURE 15.37 kb     33 Exon(s)
    MAPPING cloned Y linked   status confirmed
    Map cen - GABRA3 - MPP1 - ABCD1 - IRAK1 - FLNA - EMD EMD - PLXNA3 - G6PD - IKBKG - F8 - MTCP1 MTCP1 - SYBL1 - qter
    Authors Aradhya (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 6761 - 1871 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Nervousbrain   predominantly Homo sapiens
    Reproductivefemale systembreastmammary gland moderately
     female systemovary  moderately
    Respiratorylung   moderately
     respiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    Nervousoligodendrocyte Homo sapiensFetal
    Nervousoligodendrocyte Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Sema domain
  • four IPT/TIG domains
  • a large distinctive cytoplasmic domain
  • N- and C-terminal portions of the GAP homologous regions together form a GAP domain with an overall fold similar to other Ras GAPs
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Plxna3 (94.5 pc)
    homolog to murine Plxna3 (94.5 pc)
    intraspecies homolog to the hepatocyte growth factor receptor family
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • single-pass type I membrane protein
    • basic FUNCTION
  • involved in the development of neural and epithelial tissues
  • PLXNA3 and plexin-A4 are essential for normal sympathetic development
  • PLXNA3, PLXNA4 convey semaphorin signals during facial nerve development
  • is expressed in oligodendrocyte precursor cell (OPCs) and immature oligodendrocytes and is involved in OPC migration
  • intersection of spontaneous electrical activity with the PLXNA3 guidance molecule receptor in regulation of axon pathfinding
  • PLXNA3 signaling is modulated by spontaneous Ca2+ spike activity-dependent competition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • involved in SEMA3F-mediated oligodendrocyte precursor cell migration
  • interaction of KCNJ2 and PLXNA3
  • NRCAM stabilizes binding between NRP2 and PLXNA3 necessary for SEMA3F-induced spine pruning
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS