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FLASH GENE
Symbol GABRA3 contributors: mct - updated : 17-10-2014
HGNC name gamma-aminobutyric acid (GABA) A receptor, alpha 3
HGNC id 4077
Location Xq28      Physical location : 151.335.633 - 151.619.831
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with GABRB4, GABRE and GABRQ
STRUCTURE 288.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - DXS304 - DXS49 - DXS256 - DXS374 - DXS258 - DXS175 - DXS305 - MAGEA4 - GABRE - GABRA3 - DXS1104 - GABRB4 - DXS52 - DXS134 - DXS52 - DXS33 - DXS52 - DXS15 - BGN - qter
Authors Schlessinger (91), Palmieri (94),Levin (96),Heiss (96)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ligand binding site in the N terminal region
  • four transmembrane segments
  • one of which forming the wall of the channel
  • a large intracellular loop
    • HOMOLOGY
    Homologene
    FAMILY ligand-gated ionic channel family
    CATEGORY receptor membrane ligand ion channel , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a pentameric receptor mediating inhibitory neurotransmission
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    inducing a hyperdopaminergic phenotype, with a severe deficit in sensorimotor gating, a common feature among psychiatric conditions, including schizophrenia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target target for novel antipsychotic drugs
    ANIMAL & CELL MODELS