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FLASH GENE
Symbol MTCP1 contributors: mct - updated : 15-05-2013
HGNC name mature T-cell proliferation 1
HGNC id 7423
Corresponding disease
MTCP1 prolymphocytic leukemia (T-PLL)
Location Xq28      Physical location : 154.292.308 - 154.299.547
Synonym name
  • mature T-cell proliferation 1 isoform p13
  • mature T-cell proliferation-1 type B1
  • protein p13 MTCP-1
  • Synonym symbol(s) C6.1B, GS1-273L24.4, GS1-273L24.4, P13MTCP1, p8MTCP1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text likely 2 genes in head to head orientation
    STRUCTURE 7.24 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    DXS9879E Xq28 DNA segment on chromosome X (unique) 9879 expressed sequence UBL4 Xq28 ubiquitin-like 4 SLC10A3 Xq28 solute carrier family 10 (sodium/bile acid cotransporter family), member 3 FAM3A Xq28 family with sequence similarity 3, member A G6PD Xq28 glucose-6-phosphate dehydrogenase IKBKG Xq28 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma SPCX Xq28 SPCX LAGE2A  cancer/testis antigen 1-A CTAG1 Xq28 cancer/testis antigen 1 LOC340600 Xq28 cyclic-AMP-dependent transcription factor ATF-4 pseudogene deltaNEMO Xq28 deltaNEMO CTAG2 Xq28 cancer/testis antigen 2 LOC392561 X similar to olfactory receptor MOR255-2 GAB3 Xq28 GRB2-associated binding protein 3 DKC1 Xq28 dyskeratosis congenita 1, dyskerin MPP1 Xq28 membrane protein, palmitoylated 1, 55kDa LOC158957 Xq28 hypothetical LOC158957 F8 Xq28 coagulation factor VIII, procoagulant component (hemophilia A) HCBP6 Xq28 hepatitis C virus core-binding protein 6 MTCP1 Xq28 mature T-cell proliferation 1 C6.1A Xq28 c6.1A VBP1 Xq28 von Hippel-Lindau binding protein 1 RAB39B Xq28 RAB39B, member RAS oncogene family CLIC2 Xq28 chloride intracellular channel 2 PHF10P1 Xq28 PHD finger protein 10 pseudogene 1 F8A Xq28 coagulation factor VIII-associated (intronic transcript) H2AFB Xq28 H2A histone family, member B TMLHE Xq28 trimethyllysine hydroxylase, epsilon
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1117 8 68 - 2002 11707444
    lacks four exons which include the upstream ORF, compared to variant B1
    - - 1943 8 68 - 2002 11707444
    5 - 2329 13 107 - 2002 11707444
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Reproductivefemale systemuteruscervix  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    cysteine-rich
    HOMOLOGY
    interspecies homolog to murine Mtcp1
    intraspecies homolog to TCL1A,TCL1B
    homolog to COX17, COX23
    Homologene
    FAMILY TCL1 family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION involved in the leukemogenic process of mature T cells proliferation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with FXN
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTCP1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    t(X;14)(q28;q11) translocation in T cell prolymphocytic leukemia
    Susceptibility to hemophilia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS