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FLASH GENE

Symbol

MTCP1

contributors: mct - updated : 15-05-2013

HGNC name	mature T-cell proliferation 1
HGNC id	7423

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MTCP1 prolymphocytic leukemia (T-PLL)
Location	Xq28      Physical location : 154.292.308 - 154.299.547
Synonym name	mature T-cell proliferation 1 isoform p13
	mature T-cell proliferation-1 type B1
	protein p13 MTCP-1
Synonym symbol(s)	C6.1B, GS1-273L24.4, GS1-273L24.4, P13MTCP1, p8MTCP1

DNA

TYPE	functioning gene
SPECIAL FEATURE
text	likely 2 genes in head to head orientation
STRUCTURE	7.24 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed VA1 - - 1117 8 68 - 2002 11707444 lacks four exons which include the upstream ORF, compared to variant B1 VB1 - - 1943 8 68 - 2002 11707444 NM_001018025 5 - 2329 NP_001018025 13 107 - 2002 11707444

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Reproductive female system uterus cervix

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

cysteine-rich

HOMOLOGY

interspecies

homolog to murine Mtcp1

intraspecies	homolog to TCL1A,TCL1B
	homolog to COX17, COX23

Homologene

FAMILY

TCL1 family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION

involved in the leukemogenic process of mature T cells proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with FXN

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MTCP1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     t(X;14)(q28;q11) translocation in T cell prolymphocytic leukemia

Susceptibility

to hemophilia

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS