| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,microsome
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleolus
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| text
| localized to the plasma membrane, cytoplasm and nuclear membranes  |
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is distributed to the spindle apparatus as well as to the centrosomes at metaphase |
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higher molecular mass forms of PGRMC1 localize to the nucleus |
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PGRMC1 and SERBP1 colocalized in the cytoplasmic fractions of nondecidualized and decidualized endometrial stromal cells (ESCs) |
| basic FUNCTION
| receptor for progesterone |
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with SERBP1 complex functions in events important to early pregnancy including cellular differentiation, modulation of apoptosis and steroidogenesis |
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required for CYP7B1 function and interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism |
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mediating the anti-apoptotic action of progesterone in ovarian cells, being important regulator of the cytochrome P450 enzymes, and critical for ovarian function and maintained fertility (Mansouri 2008) |
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function through a protein kinase G-dependent mechanism (Mansouri 2008) |
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in granulosa/luteal (GL) cells PGRMC1 functions as a receptor through which progesterone activates a signal cascade that prevents apoptosis |
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role for PGRMC1 in promoting cancer-associated phenotypes |
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may mediate the non-genomic action of Progesterone and the relaxation effect on human myometrium during pregnancy |
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novel role for progesterone and PGRMC1 in regulating spindle microtubule stability during ovarian cell mitosis |
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plays a prominent role in the growth and chemoresistance of human endometrial tumors |
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role for PGRMC1 in regulating heme synthesis via interactions with FECH |
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