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Symbol PGRMC1 contributors: mct/npt - updated : 24-12-2015
HGNC name progesterone receptor membrane component 1
HGNC id 16090
Location Xq24      Physical location : 118.370.210 - 118.378.428
Synonym name
  • progesterone binding protein
  • P(4) receptor membrane component 1
  • Synonym symbol(s) MPR, HPR6.6, PGRMC
    TYPE functioning gene
    STRUCTURE 8.22 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer   transcription factor
    text structure
  • binding sites for transcription fctor like AP2, NF-AT, C/EBP
  • CpG island spanning the transcriptional start site
  • MAPPING cloned Y linked N status provisional
    Map cen - KIAA0210 - DXS7130 - PGRMC1 - DXS7340 - SLC25A5 - CXorf56 - NKRF - SEPT6 - qter
    Authors Mansouri (2008)
    Physical map
    LOC392528 X similar to beta-tubulin 1 DKFZp686L20145 Xq24 similar to rab11-binding protein LOC389882 X LOC389882 DOCK11 Xq24 dedicator of cytokinesis 11 IL13RA1 Xq22-q26 interleukin 13 receptor, alpha 1 LOC170261 Xq24 hypothetical protein LOC170261 LOC159007 Xq24 similar to Aflatoxin B1 aldehyde reductase member 2 (AFB1-AR 1) (Aldoketoreductase 7) LOC392529 X hypothetical gene supported by NM_015198 RNF127 Xq24 ring finger protein 127 KIAA1210 Xq24 KIAA1210 protein LOC389883 X similar to Hnrpa1 protein PGRMC1 Xq22-q24 progesterone receptor membrane component 1 LOC139516 Xq24 similar to DNA segment on chromosome X and Y (unique) 155 expressed sequence; Pseudoautosomal gene XE7 (Y chromosome) MRPS17P9 Xq24 similar to DNA segment on chromosome X and Y (unique) 155 expressed sequence; Pseudoautosomal gene XE7 (Y chromosome) LOC203427 Xq24 similar to solute carrier family 25 , member 16 SLC25A5 Xq24-q26 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 FLJ22965 Xq23 hypothetical protein FLJ22965 UBE2A Xq24-q25 ubiquitin-conjugating enzyme E2A (RAD6 homolog) NRF Xq24-q25 ubiquitin-conjugating enzyme E2A (RAD6 homolog) SEPT6 Xq24 ubiquitin-conjugating enzyme E2A (RAD6 homolog) LOC347454 Xq25 similar to hypothetical protein A630014H24 RPL39 Xq22.1-q22.2 ribosomal protein L39 LOC158796 Xq25 similar to UPF3 regulator of nonsense transcripts homolog B isoform 2 UPF3B Xq25-q26 UPF3 regulator of nonsense transcripts homolog B (yeast) ZNF183 Xq24-q25 zinc finger protein 183 (RING finger, C3HC4 type) NDUFA1 Xq24 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa AKAP28 Xq25 A-kinase anchor protein 28 NKAP Xq25 NF-kappaB activating protein OTEX Xq25 paired-like homeobox protein OTEX LOC392530 X similar to hypothetical protein FLJ22626 PEPP-2 Xq25 PEPP subfamily gene 2 LOC340576 Xq25 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati FLJ36576 Xq25 hypothetical protein FLJ36576 ZNF-kaiso Xq23 kaiso FLJ20716 Xq25 hypothetical protein FLJ20716 ATP1B4 Xq24 ATPase, (Na+)/K+ transporting, beta 4 polypeptide LAMP2 Xq24 lysosomal-associated membrane protein 2 RNU7P1 Xq25 RNA, U7 small nuclear pseudogene 1 RNU7P2 Xq25 RNA, U7 small nuclear pseudogene 2
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1931 21.7 195 - 2001 11697142
    2 - 1772 - 143 - 2001 11697142
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovarycorpus luteum  
     female systemovaryovarian follicle  
     female systemuterus    Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningendometrium   Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    Reproductivegranulosa cell
    Reproductivelutein cell
    cell lineage
    cell lines
    at STAGE
    physiological period embryo, pregnancy
    Text smooth muscle of placenta, vasculature capillar of trophoblast
  • short extracellular N-terminus
  • an intracellular domain containing a heme binding motif
  • a putative transmembrane domain
  • a highly conserved stretch of 58AA
  • a cytochrome b5 domain
    interspecies homolog to murine Pgrmc1
    homolog to rattus 25Dx
    homolog to Drosophila Cg9066
    intraspecies homolog to PGRMC2
  • cytochrome b5 family
  • MAPR subfamily
  • CATEGORY receptor membrane
        plasma membrane
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
  • localized to the plasma membrane, cytoplasm and nuclear membranes
  • is distributed to the spindle apparatus as well as to the centrosomes at metaphase
  • higher molecular mass forms of PGRMC1 localize to the nucleus
  • PGRMC1 and SERBP1 colocalized in the cytoplasmic fractions of nondecidualized and decidualized endometrial stromal cells (ESCs)
  • basic FUNCTION
  • receptor for progesterone
  • with SERBP1 complex functions in events important to early pregnancy including cellular differentiation, modulation of apoptosis and steroidogenesis
  • required for CYP7B1 function and interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism
  • mediating the anti-apoptotic action of progesterone in ovarian cells, being important regulator of the cytochrome P450 enzymes, and critical for ovarian function and maintained fertility (Mansouri 2008)
  • function through a protein kinase G-dependent mechanism (Mansouri 2008)
  • in granulosa/luteal (GL) cells PGRMC1 functions as a receptor through which progesterone activates a signal cascade that prevents apoptosis
  • role for PGRMC1 in promoting cancer-associated phenotypes
  • may mediate the non-genomic action of Progesterone and the relaxation effect on human myometrium during pregnancy
  • novel role for progesterone and PGRMC1 in regulating spindle microtubule stability during ovarian cell mitosis
  • plays a prominent role in the growth and chemoresistance of human endometrial tumors
  • role for PGRMC1 in regulating heme synthesis via interactions with FECH
    signaling signal transduction
    a component
  • complexing with SERBP1
  • part of a progesterone binding complex (component of the membrane complex that functions as a receptor for progesterone (P4)) (Mansouri 2008)
    small molecule other,
  • steroid (like progesterone)
  • protein
  • interacting with SERBP1 (binding partner of PGRMC1)
  • stably binds CYP51A1 (loss of PGRMC1 reduces activity of CYP51A1, blocking cholesterol synthesis and increasing production of toxic sterol intermediates)
  • PGRMC1 negatively modulates the drug-metabolizing activities of CYP2B6 through direct interaction
  • direct interaction between PGRMC1 and SUMO1, and this interaction is increased by progesterone
  • progesterone-induced BDNF release was dependent on the expression of PGRMC1
  • binds to key components of the autophagy machinery (MAP1LC3B) and is required for the degradative activity of autophagy
  • PGRMC1 may regulate FECH activity by controlling heme release
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    could mediate premature ovarian failure through altered apoptosis and thereby cause a more rapid loss of ovarian follicles (Mansouri 2008)
    Variant & Polymorphism
    Candidate gene
  • ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features
  • Therapy target
    potential therapeutic target for future hormone-based drug development for the treatment of such degenerative diseases as Alzheimer disease as well as other diseases wherein neurotrophin dysregulation is noted
    targeting PGRMC1 with a small molecule in lung and breast cancer