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FLASH GENE
Symbol PGRMC1 contributors: mct/npt - updated : 24-12-2015
HGNC name progesterone receptor membrane component 1
HGNC id 16090
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovarycorpus luteum  
 female systemovaryovarian follicle  
 female systemuterus    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
Reproductivegranulosa cell
Reproductivelutein cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text smooth muscle of placenta, vasculature capillar of trophoblast
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short extracellular N-terminus
  • an intracellular domain containing a heme binding motif
  • a putative transmembrane domain
  • a highly conserved stretch of 58AA
  • a cytochrome b5 domain
  • HOMOLOGY
    interspecies homolog to murine Pgrmc1
    homolog to rattus 25Dx
    homolog to Drosophila Cg9066
    intraspecies homolog to PGRMC2
    Homologene
    FAMILY
  • cytochrome b5 family
  • MAPR subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • localized to the plasma membrane, cytoplasm and nuclear membranes
  • is distributed to the spindle apparatus as well as to the centrosomes at metaphase
  • higher molecular mass forms of PGRMC1 localize to the nucleus
  • PGRMC1 and SERBP1 colocalized in the cytoplasmic fractions of nondecidualized and decidualized endometrial stromal cells (ESCs)
  • basic FUNCTION
  • receptor for progesterone
  • with SERBP1 complex functions in events important to early pregnancy including cellular differentiation, modulation of apoptosis and steroidogenesis
  • required for CYP7B1 function and interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism
  • mediating the anti-apoptotic action of progesterone in ovarian cells, being important regulator of the cytochrome P450 enzymes, and critical for ovarian function and maintained fertility (Mansouri 2008)
  • function through a protein kinase G-dependent mechanism (Mansouri 2008)
  • in granulosa/luteal (GL) cells PGRMC1 functions as a receptor through which progesterone activates a signal cascade that prevents apoptosis
  • role for PGRMC1 in promoting cancer-associated phenotypes
  • may mediate the non-genomic action of Progesterone and the relaxation effect on human myometrium during pregnancy
  • novel role for progesterone and PGRMC1 in regulating spindle microtubule stability during ovarian cell mitosis
  • plays a prominent role in the growth and chemoresistance of human endometrial tumors
  • role for PGRMC1 in regulating heme synthesis via interactions with FECH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with SERBP1
  • part of a progesterone binding complex (component of the membrane complex that functions as a receptor for progesterone (P4)) (Mansouri 2008)
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • steroid (like progesterone)
  • protein
  • interacting with SERBP1 (binding partner of PGRMC1)
  • stably binds CYP51A1 (loss of PGRMC1 reduces activity of CYP51A1, blocking cholesterol synthesis and increasing production of toxic sterol intermediates)
  • PGRMC1 negatively modulates the drug-metabolizing activities of CYP2B6 through direct interaction
  • direct interaction between PGRMC1 and SUMO1, and this interaction is increased by progesterone
  • progesterone-induced BDNF release was dependent on the expression of PGRMC1
  • binds to key components of the autophagy machinery (MAP1LC3B) and is required for the degradative activity of autophagy
  • PGRMC1 may regulate FECH activity by controlling heme release
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    could mediate premature ovarian failure through altered apoptosis and thereby cause a more rapid loss of ovarian follicles (Mansouri 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    potential therapeutic target for future hormone-based drug development for the treatment of such degenerative diseases as Alzheimer disease as well as other diseases wherein neurotrophin dysregulation is noted
    cancerlung 
    targeting PGRMC1 with a small molecule in lung and breast cancer
    ANIMAL & CELL MODELS