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FLASH GENE
Symbol PGRMC1 contributors: mct/npt - updated : 24-12-2015
HGNC name progesterone receptor membrane component 1
HGNC id 16090
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
could mediate premature ovarian failure through altered apoptosis and thereby cause a more rapid loss of ovarian follicles (Mansouri 2008)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    potential therapeutic target for future hormone-based drug development for the treatment of such degenerative diseases as Alzheimer disease as well as other diseases wherein neurotrophin dysregulation is noted
    cancerlung 
    targeting PGRMC1 with a small molecule in lung and breast cancer
    ANIMAL & CELL MODELS