Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PGRMC1

contributors: mct/npt - updated : 24-12-2015

HGNC name	progesterone receptor membrane component 1
HGNC id	16090

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       could mediate premature ovarian failure through altered apoptosis and thereby cause a more rapid loss of ovarian follicles (Mansouri 2008)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer potential therapeutic target for future hormone-based drug development for the treatment of such degenerative diseases as Alzheimer disease as well as other diseases wherein neurotrophin dysregulation is noted cancer lung   targeting PGRMC1 with a small molecule in lung and breast cancer

ANIMAL & CELL MODELS