Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PGRMC1 contributors: mct/npt - updated : 24-12-2015
HGNC name progesterone receptor membrane component 1
HGNC id 16090
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short extracellular N-terminus
  • an intracellular domain containing a heme binding motif
  • a putative transmembrane domain
  • a highly conserved stretch of 58AA
  • a cytochrome b5 domain
  • HOMOLOGY
    interspecies homolog to murine Pgrmc1
    homolog to rattus 25Dx
    homolog to Drosophila Cg9066
    intraspecies homolog to PGRMC2
    Homologene
    FAMILY
  • cytochrome b5 family
  • MAPR subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • localized to the plasma membrane, cytoplasm and nuclear membranes
  • is distributed to the spindle apparatus as well as to the centrosomes at metaphase
  • higher molecular mass forms of PGRMC1 localize to the nucleus
  • PGRMC1 and SERBP1 colocalized in the cytoplasmic fractions of nondecidualized and decidualized endometrial stromal cells (ESCs)
  • basic FUNCTION
  • receptor for progesterone
  • with SERBP1 complex functions in events important to early pregnancy including cellular differentiation, modulation of apoptosis and steroidogenesis
  • required for CYP7B1 function and interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism
  • mediating the anti-apoptotic action of progesterone in ovarian cells, being important regulator of the cytochrome P450 enzymes, and critical for ovarian function and maintained fertility (Mansouri 2008)
  • function through a protein kinase G-dependent mechanism (Mansouri 2008)
  • in granulosa/luteal (GL) cells PGRMC1 functions as a receptor through which progesterone activates a signal cascade that prevents apoptosis
  • role for PGRMC1 in promoting cancer-associated phenotypes
  • may mediate the non-genomic action of Progesterone and the relaxation effect on human myometrium during pregnancy
  • novel role for progesterone and PGRMC1 in regulating spindle microtubule stability during ovarian cell mitosis
  • plays a prominent role in the growth and chemoresistance of human endometrial tumors
  • role for PGRMC1 in regulating heme synthesis via interactions with FECH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with SERBP1
  • part of a progesterone binding complex (component of the membrane complex that functions as a receptor for progesterone (P4)) (Mansouri 2008)
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • steroid (like progesterone)
  • protein
  • interacting with SERBP1 (binding partner of PGRMC1)
  • stably binds CYP51A1 (loss of PGRMC1 reduces activity of CYP51A1, blocking cholesterol synthesis and increasing production of toxic sterol intermediates)
  • PGRMC1 negatively modulates the drug-metabolizing activities of CYP2B6 through direct interaction
  • direct interaction between PGRMC1 and SUMO1, and this interaction is increased by progesterone
  • progesterone-induced BDNF release was dependent on the expression of PGRMC1
  • binds to key components of the autophagy machinery (MAP1LC3B) and is required for the degradative activity of autophagy
  • PGRMC1 may regulate FECH activity by controlling heme release
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    could mediate premature ovarian failure through altered apoptosis and thereby cause a more rapid loss of ovarian follicles (Mansouri 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    potential therapeutic target for future hormone-based drug development for the treatment of such degenerative diseases as Alzheimer disease as well as other diseases wherein neurotrophin dysregulation is noted
    cancerlung 
    targeting PGRMC1 with a small molecule in lung and breast cancer
    ANIMAL & CELL MODELS