Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PFKFB2 contributors: - updated : 17-03-2006
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
HGNC id 8873
Location 1q31      Physical location : 207.226.619 - 207.254.367
Synonym symbol(s) PFK-2/FBPase-2
EC.number 2.7.1.105, 3.1.3.46
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     16 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20 IL24 1q32 interleukin 24 TOSO 1q32.1 regulator of Fas-induced apoptosis PIGR 1q32 polymeric immunoglobulin receptor FKSG87 1q32.1 FKSG87 protein LOC387623 1 hypothetical gene supported by NM_024115 SARG 1q32.1 specifically androgen-regulated protein DKFZp451J1719 1q32.1 hypothetical DKFZp451J1719 PFKFB2 1q31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 C4BPB 1q32 complement component 4 binding protein, beta C4BPA 1q32 complement component 4 binding protein, alpha LOC343024 1q32.1 similar to C4BP alpha chain precursor - rabbit C4BPAL2 1q32 complement component 4 binding protein, alpha-like 2 DAF 1q32 decay accelerating factor for complement (CD55, Cromer blood group system) FLJ13310 1q32.1 hypothetical protein FLJ13310 CR2 1q32 complement component (3d/Epstein Barr virus) receptor 2 CR1 1q32 complement component (3b/4b) receptor 1, including Knops blood group system CR1L 1q32 complement component (3b/4b) receptor 1-like MCP 1q32 membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 7073 58 505 - Kessler
  • containing exons 1 to 15
  • - splicing 3529 54 471 heart Soejima, Kessler
  • containing exons 1 to 14 and 16
  • differing in the 3' UTR and coding region compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon moderately
     pancreas exocrine   moderately
    Endocrinethyroid   predominantly
    Lymphoid/Immunespleen   moderately
     thymus   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
     male systemtestis  moderately
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  moderately
    Skin/Tegumentskin   highly
    Urinarybladder   moderately
     kidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP binding site
  • two fructose-6-phosphate binding site
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to chimpanzee pfkfb2
    ortholog to rattus Pfkfb2
    ortholog to murine Pfkfb2
    Homologene
    FAMILY
  • phosphoglycerate mutase family, in the C-terminal section
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a 6-phosphofructo-2-kinase
  • acting as a fructose 2,6-biphosphatase 2
  • involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • synthesis and degradation of fructose 2,6-bisphosphate
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • ATP
  • fructose-6-phosphate
  • protein
    cell & other
    REGULATION
    activated by phosphorylation, for the kinase activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS