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FLASH GENE
Symbol PFKFB2 contributors: - updated : 17-03-2006
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
HGNC id 8873
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 7073 58 505 - Kessler
  • containing exons 1 to 15
  • - splicing 3529 54 471 heart Soejima, Kessler
  • containing exons 1 to 14 and 16
  • differing in the 3' UTR and coding region compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon moderately
     pancreas exocrine   moderately
    Endocrinethyroid   predominantly
    Lymphoid/Immunespleen   moderately
     thymus   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
     male systemtestis  moderately
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  moderately
    Skin/Tegumentskin   highly
    Urinarybladder   moderately
     kidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP binding site
  • two fructose-6-phosphate binding site
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to chimpanzee pfkfb2
    ortholog to rattus Pfkfb2
    ortholog to murine Pfkfb2
    Homologene
    FAMILY
  • phosphoglycerate mutase family, in the C-terminal section
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a 6-phosphofructo-2-kinase
  • acting as a fructose 2,6-biphosphatase 2
  • involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • synthesis and degradation of fructose 2,6-bisphosphate
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • ATP
  • fructose-6-phosphate
  • protein
    cell & other
    REGULATION
    activated by phosphorylation, for the kinase activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS